BACKGROUND: Children with sickle cell disease (SCD) often undergo MRI studies to assess brain injury or to quantify hepatic iron. MRI requires the child to lie motionless for 30-60 min, thus sedation/anesthesia might be used to facilitate successful completion of exams, but this poses additional risks for SCD patients. To improve children's ability to cope with MRI examinations and avoid sedation, our institution established preparation and support procedures (PSP). OBJECTIVE: To investigate the impact of PSP in reducing the need for sedation during MRI exams among children with SCD. MATERIALS AND METHODS: Data on successful completion of MRI testing were compared among 5- to 12-year-olds who underwent brain MRI or liver R2*MRI with or without receiving PSP. RESULTS: Seventy-one children with SCD (median age 9.85 years, range 5.57-12.99 years) underwent a brain MRI (n = 60) or liver R2*MRI (n = 11). Children who received PSP were more likely to complete an interpretable MRI exam than those who did not (30 of 33; 91% vs. 27 of 38; 71%, unadjusted OR = 4.1 (P = 0.04) and OR = 8.5 (P < 0.01) when adjusting for age. CONCLUSION: PSP can help young children with SCD complete clinically interpretable, nonsedated MRI exams, avoiding the risks of sedation/anesthesia.
BACKGROUND:Children with sickle cell disease (SCD) often undergo MRI studies to assess brain injury or to quantify hepatic iron. MRI requires the child to lie motionless for 30-60 min, thus sedation/anesthesia might be used to facilitate successful completion of exams, but this poses additional risks for SCDpatients. To improve children's ability to cope with MRI examinations and avoid sedation, our institution established preparation and support procedures (PSP). OBJECTIVE: To investigate the impact of PSP in reducing the need for sedation during MRI exams among children with SCD. MATERIALS AND METHODS: Data on successful completion of MRI testing were compared among 5- to 12-year-olds who underwent brain MRI or liver R2*MRI with or without receiving PSP. RESULTS: Seventy-one children with SCD (median age 9.85 years, range 5.57-12.99 years) underwent a brain MRI (n = 60) or liver R2*MRI (n = 11). Children who received PSP were more likely to complete an interpretable MRI exam than those who did not (30 of 33; 91% vs. 27 of 38; 71%, unadjusted OR = 4.1 (P = 0.04) and OR = 8.5 (P < 0.01) when adjusting for age. CONCLUSION:PSP can help young children with SCD complete clinically interpretable, nonsedated MRI exams, avoiding the risks of sedation/anesthesia.
Authors: Monica L Hulbert; Robert C McKinstry; JoAnne L Lacey; Christopher J Moran; Julie A Panepinto; Alexis A Thompson; Sharada A Sarnaik; Gerald M Woods; James F Casella; Baba Inusa; Jo Howard; Fenella J Kirkham; Kofi A Anie; Jonathan E Mullin; Rebecca Ichord; Michael Noetzel; Yan Yan; Mark Rodeghier; Michael R Debaun Journal: Blood Date: 2010-10-12 Impact factor: 22.113
Authors: M Koshy; S J Weiner; S T Miller; L A Sleeper; E Vichinsky; A K Brown; Y Khakoo; T R Kinney Journal: Blood Date: 1995-11-15 Impact factor: 22.113
Authors: Nora M Raschle; Michelle Lee; Roman Buechler; Joanna A Christodoulou; Maria Chang; Monica Vakil; Patrice L Stering; Nadine Gaab Journal: J Vis Exp Date: 2009-07-30 Impact factor: 1.355
Authors: Breya Walker; Heather M Conklin; Doralina L Anghelescu; Lacey P Hall; Wilburn E Reddick; Robert Ogg; Lisa M Jacola Journal: Support Care Cancer Date: 2017-12-19 Impact factor: 3.603
Authors: Naama Barnea-Goraly; Stuart A Weinzimer; Katrina J Ruedy; Nelly Mauras; Roy W Beck; Matt J Marzelli; Paul K Mazaika; Tandy Aye; Neil H White; Eva Tsalikian; Larry Fox; Craig Kollman; Peiyao Cheng; Allan L Reiss Journal: Pediatr Radiol Date: 2013-10-06
Authors: Shawna Grissom; Jessika Boles; Katherine Bailey; Kathryn Cantrell; Amy Kennedy; April Sykes; Belinda N Mandrell Journal: Support Care Cancer Date: 2015-12-04 Impact factor: 3.603