BACKGROUND: Roux-en-Y gastric bypass (RYGB) surgery is the gold standard surgical treatment for obesity. However, unintended nutritional deficiencies following this surgery are common, including changes in bone metabolism. We assessed changes in bone mineral density (BMD), nutritional compounds, and bone resorption markers before and 1 year following RYGB surgery. METHODS: Our study included 22 female patients with class II/III obesity. A clinical questionnaire, a 24-h recall, blood and urine samples, and dual-energy X-ray absorptiometry were provided. RESULTS: Mean age was 37.2 ± 9.6 years; 86 % were Caucasian and 77.2 % were premenopausal. Mean preoperative body mass index was 44.4 ± 5.0 and 27.5 ± 4.5 kg/m(2) at 1-year follow-up (p < 0.001). 25-OH-vitamin D-levels were similar in both periods [11.7 (9.7-18.0) vs. 15.7 (10.2-2.7) pg/dL, p = 0.327]. Serum N-telopeptide (16.3 ± 3.4 vs. 38.2 ± 7.0 nM BCE, p < 0.001) and parathyroid hormone (45.4 ± 16.7 vs. 62.7 ± 28.9 pg/mL, p = 0.026) increased after RYGB surgery, reflecting bone resorption. BMD decreased after RYGB surgery in the lumbar spine (1.13 ± 0.11 vs. 1.04 ± 0.09 g/cm(2), p = 0.001), femoral neck (1.03 ± 0.15 vs. 0.94 ± 0.16 g/cm(2), p = 0.001), and total femur (1.07 ± 0.11 vs. 0.97 ± 0.15 g/cm(2), p = 0.003). CONCLUSIONS: Decreased BMD in the lumbar spine, femoral neck, and total femur is detectable in women 1 year after RYGB surgery. Calcium malabsorption, caused by vitamin D deficiency and increased bone resorption, is partially responsible for these outcomes and should be targeted in future clinical trials.
BACKGROUND: Roux-en-Y gastric bypass (RYGB) surgery is the gold standard surgical treatment for obesity. However, unintended nutritional deficiencies following this surgery are common, including changes in bone metabolism. We assessed changes in bone mineral density (BMD), nutritional compounds, and bone resorption markers before and 1 year following RYGB surgery. METHODS: Our study included 22 female patients with class II/III obesity. A clinical questionnaire, a 24-h recall, blood and urine samples, and dual-energy X-ray absorptiometry were provided. RESULTS: Mean age was 37.2 ± 9.6 years; 86 % were Caucasian and 77.2 % were premenopausal. Mean preoperative body mass index was 44.4 ± 5.0 and 27.5 ± 4.5 kg/m(2) at 1-year follow-up (p < 0.001). 25-OH-vitamin D-levels were similar in both periods [11.7 (9.7-18.0) vs. 15.7 (10.2-2.7) pg/dL, p = 0.327]. Serum N-telopeptide (16.3 ± 3.4 vs. 38.2 ± 7.0 nM BCE, p < 0.001) and parathyroid hormone (45.4 ± 16.7 vs. 62.7 ± 28.9 pg/mL, p = 0.026) increased after RYGB surgery, reflecting bone resorption. BMD decreased after RYGB surgery in the lumbar spine (1.13 ± 0.11 vs. 1.04 ± 0.09 g/cm(2), p = 0.001), femoral neck (1.03 ± 0.15 vs. 0.94 ± 0.16 g/cm(2), p = 0.001), and total femur (1.07 ± 0.11 vs. 0.97 ± 0.15 g/cm(2), p = 0.003). CONCLUSIONS: Decreased BMD in the lumbar spine, femoral neck, and total femur is detectable in women 1 year after RYGB surgery. Calcium malabsorption, caused by vitamin D deficiency and increased bone resorption, is partially responsible for these outcomes and should be targeted in future clinical trials.
Authors: Xavier Nogués; Albert Goday; Maria Jesus Peña; David Benaiges; Marta de Ramón; Xenia Crous; Manuel Vial; Manuel Pera; Luis Grande; Adolfo Díez-Pérez; Jose Manuel Ramón Journal: Cir Esp Date: 2010-07-08 Impact factor: 1.653
Authors: P Mezquita-Raya; M Muñoz-Torres; J D Luna; V Luna; F Lopez-Rodriguez; E Torres-Vela; F Escobar-Jiménez Journal: J Bone Miner Res Date: 2001-08 Impact factor: 6.741
Authors: R Eastell; N Mallinak; S Weiss; M Ettinger; M Pettinger; D Cain; K Fressland; C Chesnut Journal: J Bone Miner Res Date: 2000-03 Impact factor: 6.741
Authors: Bárbara C Carvalho Silva; Bruno Muzzi Camargos; Julienne Borges Fujii; Eduardo Pimentel Dias; Maria Marta Sarquis Soares Journal: Arq Bras Endocrinol Metabol Date: 2008-04
Authors: C Gronnier; F Tremollieres; Blandine Gatta-Cherifi; O Cadart; O Degrandi; T Barnetche; N Mehsen-Cetre; M Monsaingeon-Henry; E Pupier; L Bosc; D Collet Journal: Obes Surg Date: 2020-09 Impact factor: 4.129
Authors: Lingtak-Neander Chan; Charlotte H Neilson; Elizabeth A Kirk; Tiana F Colovos; Diane R Javelli; Saurabh Khandelwal Journal: Obes Surg Date: 2015-12 Impact factor: 4.129