OBJECTIVE: For about 30% of epilepsy patients, pharmaceutical therapy fails to control their seizures. MR-guided laser interstitial thermal therapy (MRgLITT) allows for real-time thermal monitoring of the ablation process and feedback control over the laser energy delivery. We report on minimally invasive surgical techniques of MRgLITT and short-term follow-up results from the first five pediatric cases in which this system was used to ablate focal epileptic lesions. METHODS: We studied the patients with MRI of the brain, localized the seizure with video-EEG and used the Visualase Thermal Therapy 25 System for laser ablation of their seizure foci. RESULTS: All 5 patients are seizure free and there were no complications as of 2-13-month follow-up. CONCLUSION: MR-guided laser interstitial thermal therapy has a significant potential to be a minimally invasive alternative to more conventional techniques to surgically treat medically refractory epilepsy in children.
OBJECTIVE: For about 30% of epilepsypatients, pharmaceutical therapy fails to control their seizures. MR-guided laser interstitial thermal therapy (MRgLITT) allows for real-time thermal monitoring of the ablation process and feedback control over the laser energy delivery. We report on minimally invasive surgical techniques of MRgLITT and short-term follow-up results from the first five pediatric cases in which this system was used to ablate focal epileptic lesions. METHODS: We studied the patients with MRI of the brain, localized the seizure with video-EEG and used the Visualase Thermal Therapy 25 System for laser ablation of their seizure foci. RESULTS: All 5 patients are seizure free and there were no complications as of 2-13-month follow-up. CONCLUSION: MR-guided laser interstitial thermal therapy has a significant potential to be a minimally invasive alternative to more conventional techniques to surgically treat medically refractory epilepsy in children.
Authors: E Yeniaras; D T Fuentes; S J Fahrenholtz; J S Weinberg; F Maier; J D Hazle; R J Stafford Journal: Int J Comput Assist Radiol Surg Date: 2013-10-05 Impact factor: 2.924
Authors: Hepzibha Alexander; Kelsey Cobourn; Islam Fayed; Dewi Depositario-Cabacar; Robert F Keating; William D Gaillard; Chima O Oluigbo Journal: Childs Nerv Syst Date: 2019-01-09 Impact factor: 1.475
Authors: Andrew T Hale; Sonali Sen; Ali S Haider; Freedom F Perkins; Dave F Clarke; Mark R Lee; Luke D Tomycz Journal: Neurosurgery Date: 2019-10-01 Impact factor: 4.654