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Literature DB >> 22682242

Getting RNA and protein in phase.

Stephanie C Weber¹, Clifford P Brangwynne.

Abstract

Nonmembrane-bound organelles such as RNA granules behave like dynamic droplets, but the molecular details of their assembly are poorly understood. Several recent papers identify structural features that drive granule assembly, shedding light on how phase transitions functionally organize the cell and may lead to pathological protein aggregation.

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Year: 2012 PMID： 22682242 DOI： 10.1016/j.cell.2012.05.022

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

213 in total

1. Polyphosphate granule biogenesis is temporally and functionally tied to cell cycle exit during starvation in Pseudomonas aeruginosa.

Authors: Lisa R Racki; Elitza I Tocheva; Michael G Dieterle; Meaghan C Sullivan; Grant J Jensen; Dianne K Newman
Journal: Proc Natl Acad Sci U S A Date: 2017-03-06 Impact factor: 11.205

Getting RNA and protein in phase.

1. Polyphosphate granule biogenesis is temporally and functionally tied to cell cycle exit during starvation in Pseudomonas aeruginosa.

2. Alu element-containing RNAs maintain nucleolar structure and function.

3. Phosphorylation-mediated RNA/peptide complex coacervation as a model for intracellular liquid organelles.

Review 4. Stress granules and cell signaling: more than just a passing phase?

5. Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome.

6. Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons.

7. From sequence and forces to structure, function, and evolution of intrinsically disordered proteins.

Review 8. More than Just a Phase: Prions at the Crossroads of Epigenetic Inheritance and Evolutionary Change.

Review 9. The biology of boundary conditions: cellular reconstitution in one, two, and three dimensions.

10. Cytoplasmic RNA Granules and Viral Infection.