Literature DB >> 2265552

Cytogenetic analysis of human solid tumors by in situ hybridization with a set of 12 chromosome-specific DNA probes.

H van Dekken1, J G Pizzolo, V E Reuter, M R Melamed.   

Abstract

We have applied fluorescent in situ hybridization (FISH) to assess the presence of numerical chromosome aberrations in fresh specimens of human solid tumors of varying histology. For this purpose, a set of 12 biotinylated chromosome-specific, repetitive alpha-satellite DNA probes (for chromosomes 1, 6, 7, 9, 10, 11, 15, 16, 17, 18, X and Y) were hybridized directly to isolated interphase nuclei. Utilizing this approach, we found numerical chromosome changes in all tumors. FISH ploidy profiles were in accordance with flow cytometric DNA histograms of these tumor cells.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2265552     DOI： 10.1159/000132971

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  13 in total

1.  FISHing chromosomes in endocrinology.

Authors:  G Kontogeorgos; K Kovacs
Journal:  Endocrine       Date:  1996-12       Impact factor: 3.633

2.  Interphase cytogenetics in paraffin sections of lung tumors by non-isotopic in situ hybridization. Mapping genotype/phenotype heterogeneity.

Authors:  S Y Kim; J S Lee; J Y Ro; M L Gay; W K Hong; W N Hittelman
Journal:  Am J Pathol       Date:  1993-01       Impact factor: 4.307

3.  Interphase in situ hybridization to disaggregated and intact tissue specimens of prostatic adenocarcinomas.

Authors:  J C Alers; P J Krijtenburg; K J Vissers; S K Krishnadath; F T Bosman; H van Dekken
Journal:  Histochem Cell Biol       Date:  1995-12       Impact factor: 4.304

4.  Study of numerical aberrations of chromosome 1 by fluorescent in situ hybridization and DNA content by densitometric analysis on (pre)-malignant cervical lesions.

Authors:  P Segers; S Haesen; P Castelain; J J Amy; P De Sutter; P Van Dam; M Kirsch-Volders
Journal:  Histochem J       Date:  1995-01

Review 5.  Spatial analysis of intranuclear human repetitive DNA regions by in situ hybridization and digital fluorescence microscopy.

Authors:  H van Dekken; R Hulspas
Journal:  Histochem J       Date:  1993-03

6.  Flow cytometric and cytogenetic analyses in human spontaneous abortions.

Authors:  R De Vita; A Calugi; D Cavallo; P Eleuteri; A Vizzone
Journal:  Hum Genet       Date:  1993-06       Impact factor: 4.132

Review 7.  Detection of genomic changes in cancer by in situ hybridization.

Authors:  A H Hopman; C E Voorter; F C Ramaekers
Journal:  Mol Biol Rep       Date:  1994-01       Impact factor: 2.316

8.  Phosphoinositide-specific Phospholipase C β1 gene deletion in bipolar disorder affected patient.

Authors:  Vincenza Rita Lo Vasco; Lucia Longo; Patrizia Polonia
Journal:  J Cell Commun Signal       Date:  2012-11-17       Impact factor: 5.782

9.  Genetics of uveal melanoma and cutaneous melanoma: two of a kind?

Authors:  Thomas van den Bosch; Emine Kilic; Dion Paridaens; Annelies de Klein
Journal:  Dermatol Res Pract       Date:  2010-06-06

10.  Expression of the SST receptor 2 in uveal melanoma is not a prognostic marker.

Authors:  Mariam Kouch-el Filali; Emine Kilic; Marleen Melis; Annelies de Klein; Marion de Jong; Gregorius P M Luyten
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2008-08-06       Impact factor: 3.117
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.