| Literature DB >> 22633074 |
M N Shamsudin1, M A Alreshidi, R A Hamat, A S Alshrari, S S Atshan, V Neela.
Abstract
The minimum inhibitory concentrations (MICs) of 60 meticillin-resistant Staphylococcus aureus (MRSA) isolates from Malaysia to three antiseptic agents - benzalkonium chloride (BZT), benzethonium chloride (BAC) and chlorhexidine digluconate (CHG) - were determined. All isolates had MICs ranging from 0.5 to 2 mg/L. Antiseptic resistance genes qacA/B and smr were detected in 83.3% and 1.6% of the isolates, respectively. Carriage of qacA/B correlated with reduced susceptibility to CHG and BAC. This is the first report of the prevalence of qacA/B and smr gene carriage in Malaysian MRSA isolates, with a high frequency of qacA/B carriage. The presence of these antiseptic resistance genes and associated reduced susceptibility to antiseptic agents may have clinical implications.Entities:
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Year: 2012 PMID： 22633074 DOI： 10.1016/j.jhin.2012.04.015
Source DB: PubMed Journal: J Hosp Infect ISSN： 0195-6701 Impact factor: 3.926