Literature DB >> 226300

An approach to the routine estimation of circulating carcinoembryonic antigen immune complexes in patients with carcinomata of the gastrointestinal tract.

K Kapsopoulou-Dominos, F A Anderer.   

Abstract

The carcinoembryonic antigen (CEA) distribution obtained after fractionation of thirty sera of patients with gastrointestinal tumours by gel filtration in Sephadex G200 was compared with that resulting from extraction of the sera with perchloric acid. In all cases gel filtration yielded a fraction of free CEA and in twenty-three cases an additional fraction of CEA immune complexes. The amounts of free CEA corresponded fairly well to the fractions of CEA which could be extracted by perchloric acid. The CEA content of the fraction containing CEA immune complexes was comparable to the CEA content of the perchloric acid precipitates. The presence of CEA immune complexes in the perchloric acid precipitates could be demonstrated by gel filtration under dissociating andnon-dissociating conditions and after pre-incubation with 125I-CEA by radioimmuno-double-diffusion using monospecific rabbit antisera against human IgM and IgG.

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Year:  1979        PMID： 226300      PMCID： PMC1537670     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  22 in total

Review 1.  Heterogeneity of carcinoembryonic antigen. Implications on its role as a tumour marker substance.

Authors:  G T Rogers
Journal:  Biochim Biophys Acta       Date:  1976-12-23

2.  [Computer-supported postoperative CEA-course controls : correlation with the prognosis of recurrence and findings of second-look operations].

Authors:  H J Staab; F A Anderer; E Stumpf; R Fischer
Journal:  Z Gastroenterol Verh       Date:  1976

3.  Circulating carcinoembryonic antigen immune complexes in sera of patients with carcinomata of the gastrointestinal tract.

Authors:  K Kapsopoulou-Dominos; F A Anderer
Journal:  Clin Exp Immunol       Date:  1979-02       Impact factor: 4.330

4.  Carcinoembryonic antigen follow-up and selection of patients for second-look operation in management of gastrointestinal carcinoma.

Authors:  H J Staab; F A Anderer; E Stumpf; R Fischer
Journal:  J Surg Oncol       Date:  1978       Impact factor: 3.454

5.  The use of CEA as an early indicator for gastrointestinal tumor recurrence and second-look procedures.

Authors:  E W Martin; K K James; P E Hurtubise; P Catalano; J P Minton
Journal:  Cancer       Date:  1977-02       Impact factor: 6.860

6.  Patterns of serial CEA assays and their clinical use in management of colorectal cancer.

Authors:  P H Sugarbaker; A T Skarin; N Zamcheck
Journal:  J Surg Oncol       Date:  1976       Impact factor: 3.454

7.  Suggestive evidence that the "blocking antibodies" of tumor-bearing individuals may be antigen--antibody complexes.

Authors:  H O Sjögren; I Hellström; S C Bansal; K E Hellström
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205

8.  Extraction of CEA from tumour tissue, foetal colon and patients' sera, and the effect of perchloric acid.

Authors:  P A Keep; B A Leake; G T Rogers
Journal:  Br J Cancer       Date:  1978-02       Impact factor: 7.640

9.  DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES.

Authors:  P GOLD; S O FREEDMAN
Journal:  J Exp Med       Date:  1965-03-01       Impact factor: 14.307

10.  Analysis of inhibition of lymphocyte cytotoxicity in human colon carcinoma.

Authors:  A P Nind; N Matthews; E A Pihl; J M Rolland; R C Nairn
Journal:  Br J Cancer       Date:  1975-06       Impact factor: 7.640
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  8 in total

Review 1.  Immune complexes in human diseases: a review.

Authors:  A N Theofilopoulos; F J Dixon
Journal:  Am J Pathol       Date:  1980-08       Impact factor: 4.307

2.  [Relapse prognosis for patients with adenocarcinoma of the gastrointestinal tract on the basis of carcinoembryonic antigen (CEA) and its circulating immune complexes (author's transl)].

Authors:  H J Staab; F A Anderer; E Stumpf; R Fischer
Journal:  Klin Wochenschr       Date:  1980-02-01

3.  Circulating immune complexes (CIC), carcinoembryonic antigen (CEA) and CIC containing CEA as markers for colorectal cancer.

Authors:  K A Chester; R H Begent
Journal:  Clin Exp Immunol       Date:  1984-12       Impact factor: 4.330

4.  CEA-containing immune complexes in sera of patients with colorectal and breast cancer--analysis of complexed immunoglobulin classes.

Authors:  C Fuchs; F Krapf; P Kern; S Hoferichter; W Jäger; J R Kalden
Journal:  Cancer Immunol Immunother       Date:  1988       Impact factor: 6.968

5.  Immune response to the carcinoembryonic antigen in patients treated with an anti-idiotype antibody vaccine.

Authors:  K A Foon; M Chakraborty; W J John; A Sherratt; H Köhler; M Bhattacharya-Chatterjee
Journal:  J Clin Invest       Date:  1995-07       Impact factor: 14.808

6.  The presence of anti-carcinoembryonic antigen (CEA) antibodies in the sera of patients with gastrointestinal malignancies.

Authors:  M M Konstadoulakis; K N Syrigos; C Albanopoulos; G Mayers; B Golematis
Journal:  J Clin Immunol       Date:  1994-09       Impact factor: 8.317

7.  A rapid method for the determination of human CEA/mouse anti-CEA immune complexes in patients undergoing immunoscintigraphy.

Authors:  R P Baum; P H Driever; D Drahovsky; G Hör
Journal:  Eur J Nucl Med       Date:  1989

Review 8.  Biological therapy: approaches in colorectal cancer. Strategies to enhance carcinoembryonic antigen (CEA) as an immunogenic target.

Authors:  A P Zbar; N R Lemoine; M Wadhwa; H Thomas; D Snary; W A Kmiot
Journal:  Br J Cancer       Date:  1998-03       Impact factor: 7.640
  8 in total

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