Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A rapid method for the determination of human CEA/mouse anti-CEA immune complexes in patients undergoing immunoscintigraphy.

Literature DB >> 2767081

A rapid method for the determination of human CEA/mouse anti-CEA immune complexes in patients undergoing immunoscintigraphy.

R P Baum¹, P H Driever, D Drahovsky, G Hör.

Abstract

We report here on a new and quick procedure to isolate human (hu) CEA mouse anti CEA immune complexes of sera from patients admitted for immunoscintigraphy with radiolabeled monoclonal anti CEA antibody. This method employs rabbit anti mouse IgG immune affinity chromatography together with a commercial CEA-IRMA kit for the specific isolation of immune complexes. By applying this procedure we were able to show that immune complex formation increased in parallel to CEA serum concentration. The formation of immune complexes did not significantly affect tumor detection by immunoscintigraphy.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2767081 DOI： 10.1007/BF00435473

Source DB: PubMed Journal: Eur J Nucl Med ISSN： 0340-6997

17 in total

1. The in vivo localization of anti-Wagner-osteogenic-sarcoma antibodies.

Authors: D PRESSMAN; L KORNGOLD
Journal: Cancer Date: 1953-05 Impact factor: 6.860

2. Carcinoembryonic antigen-binding immunoglobulin isolated from normal human serum by affinity chromatography.

Authors: D Pressman; T M Chu; A L Grossberg
Journal: J Natl Cancer Inst Date: 1979-06 Impact factor: 13.506

3. Tumor localization in patients by radiolabeled monoclonal antibodies against colon carcinoma.

Authors: J P Mach; J F Chatal; J D Lumbroso; F Buchegger; M Forni; J Ritschard; C Berche; J Y Douillard; S Carrel; M Herlyn
Journal: Cancer Res Date: 1983-11 Impact factor: 12.701

4. Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning.

Authors: D M Goldenberg; F DeLand; E Kim; S Bennett; F J Primus; J R van Nagell; N Estes; P DeSimone; P Rayburn
Journal: N Engl J Med Date: 1978-06-22 Impact factor: 91.245

5. Monoclonal antibodies to carcinoembryonic antigen produced by somatic cell fusion.

Authors: H Z Kupchik; V R Zurawski; J G Hurrell; N Zamcheck; P H Black
Journal: Cancer Res Date: 1981-09 Impact factor: 12.701

6. Imaging with 131I-labeled monoclonal antibodies to a high-molecular-weight melanoma-associated antigen in patients with melanoma: efficacy of whole immunoglobulin and its F(ab')2 fragments.

Authors: G L Buraggi; L Callegaro; G Mariani; A Turrin; N Cascinelli; A Attili; E Bombardieri; G Terno; G Plassio; M Dovis
Journal: Cancer Res Date: 1985-07 Impact factor: 12.701

7. Immunoscintigraphy of colon carcinoma.

Authors: J F Chatal; J C Saccavini; P Fumoleau; J Y Douillard; C Curtet; M Kremer; B Le Mevel; H Koprowski
Journal: J Nucl Med Date: 1984-03 Impact factor: 10.057

8. Circulating immune complexes in cancer patients receiving goat radiolocalizing antibodies to carcinoembryonic antigen.

Authors: F J Primus; S J Bennett; E E Kim; F H DeLand; M C Zahn; D M Goldenberg
Journal: Cancer Res Date: 1980-03 Impact factor: 12.701

9. Tumor localization of radiolabeled antibodies against carcinoembryonic antigen in patients with carcinoma: a critical evaluation.

Authors: J P Mach; S Carrel; M Forni; J Ritschard; A Donath; P Alberto
Journal: N Engl J Med Date: 1980-07-03 Impact factor: 91.245