Literature DB >> 22625410

Chemistry and biology of indoles and indazoles: a mini-review.

Nasir Ali Shafakat Ali1, Bashir Ahmad Dar, Vidya Pradhan, Mazahar Farooqui.   

Abstract

The present review article is related with the method of preparation, importance and medicinal application of indole and indazoles. The studies of heterocycles is an evergreen field in the branch of organic chemistry and always attract the attention of chemists working not only in the area of natural products but also in the synthetic chemistry. Moreover many useful drugs have emerged from the successful investigation carried out in this branch. The derivatives of indoles and indazoles exhibits antibacterial, anticancer, antionidants, anti-inflammatory, antidiabetic, antiviral, atniproliferative, antituberculosis, antispermetogenic activity, antipsychotic drugs etc.

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Year:  2013        PMID: 22625410     DOI: 10.2174/1389557511313120009

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN: 1389-5575            Impact factor:   3.862


  10 in total

1.  Divergent Reactivity of Rhodium(I) Carbenes Derived from Indole Annulations.

Authors:  Xiaoxun Li; Hui Li; Wangze Song; Po-Sen Tseng; Lingyan Liu; Ilia A Guzei; Weiping Tang
Journal:  Angew Chem Int Ed Engl       Date:  2015-09-07       Impact factor: 15.336

Review 2.  Isocyanide-Based Multicomponent Reactions in Water: Advanced Green Tools for the Synthesis of Heterocyclic Compounds.

Authors:  Siamak Javanbakht; Mohammad Taghi Nazeri; Hassan Farhid; Tahereh Nasiriani; Vida Khodkari; Ahmad Shaabani
Journal:  Top Curr Chem (Cham)       Date:  2022-09-22

3.  3,39-Diindolylmethane Ameliorates Staphylococcal Enterotoxin B–Induced Acute Lung Injury through Alterations in the Expression of MicroRNA that Target Apoptosis and Cell-Cycle Arrest in Activated T Cells.

Authors:  David M Elliott; Mitzi Nagarkatti; Prakash S Nagarkatti
Journal:  J Pharmacol Exp Ther       Date:  2016-04       Impact factor: 4.030

4.  Dual vicinal functionalisation of heterocycles via an interrupted Pummerer coupling/[3,3]-sigmatropic rearrangement cascade.

Authors:  Mindaugas Šiaučiulis; Selma Sapmaz; Alexander P Pulis; David J Procter
Journal:  Chem Sci       Date:  2017-11-17       Impact factor: 9.825

5.  Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles.

Authors:  Mei-Huey Lin; Kung-Yu Liang; Chang-Hsien Tsai; Yu-Chun Chen; Hung-Chang Hsiao; Yi-Syuan Li; Chung-Hao Chen; Hau-Chun Wu
Journal:  Molecules       Date:  2016-02-19       Impact factor: 4.411

6.  In-Vitro Antioxidant, Hypoglycemic Activity, and Identification of Bioactive Compounds in Phenol-Rich Extract from the Marine Red Algae Gracilaria edulis (Gmelin) Silva.

Authors:  Thilina L Gunathilaka; Kalpa W Samarakoon; P Ranasinghe; L Dinithi C Peiris
Journal:  Molecules       Date:  2019-10-15       Impact factor: 4.411

7.  Indole-3-acetamides: As Potential Antihyperglycemic and Antioxidant Agents; Synthesis, In Vitro α-Amylase Inhibitory Activity, Structure-Activity Relationship, and In Silico Studies.

Authors:  Khalid Mohammed Khan; Sridevi Chigurupati; Farman Ali; Munissa Younus; Maha Aldubayan; Abdul Wadood; Huma Khan; Muhammad Taha; Shahnaz Perveen
Journal:  ACS Omega       Date:  2021-01-12

8.  Facile synthesis and biological evaluation of tryptamine-piperazine-2,5-dione conjugates as anticancer agents.

Authors:  Jiang-Ping Meng; Shi-Qiang Li; Yan Tang; Zhi-Gang Xu; Zhong-Zhu Chen; Li-Xia Gao
Journal:  RSC Adv       Date:  2021-08-17       Impact factor: 4.036

9.  Catalyst-Free One-Pot Synthesis of Densely Substituted Pyrazole-Pyrazines as Anti-Colorectal Cancer Agents.

Authors:  Jia Xu; Hong-Bo Tan; Ya-Jun Zhang; Dian-Yong Tang; Fenghuang Zhan; Hong-Yu Li; Zhong-Zhu Chen; Zhi-Gang Xu
Journal:  Sci Rep       Date:  2020-06-09       Impact factor: 4.379

10.  Synthesis, Molecular Docking Analysis and in Vitro Biological Evaluation of Some New Heterocyclic Scaffolds-Based Indole Moiety as Possible Antimicrobial Agents.

Authors:  Entesar A Hassan; Ihsan A Shehadi; Awatef M Elmaghraby; Hadir M Mostafa; Salem E Zayed; Aboubakr H Abdelmonsef
Journal:  Front Mol Biosci       Date:  2022-01-17
  10 in total

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