Xiangqi Li1, Xianigguo Dang, Xibo Sun. 1. Department of General Surgery, Affiliated Hospital of Taishan Medical College, Taian, China. drlixqi@hotmail.com
Abstract
PURPOSE: To study the expression of survivin and VEGF-C in breast cancer tissue and its relation to lymphatic metastasis. METHODS: The expression level of survivin and VEGF-C in breast cancer tissue is determined by immunohistochemistry and reverse transcriptase polymerase chain reaction (Rt-PCR). RESULTS: Among the 60 breast cancer tissues, the percentage of positive expression of survivin or VEGF-C was 85.0% and 78.3%, respectively. The expression rate of VEGF-C was 84.3% (43/51), 44.4% (4/9) in the survivin positive and negative expression group, respectively. Linear correlation analysis showed a correlation coefficient of survivin and VEGF-C in breast cancer was 0.80 (p = 0.035), which indicates a positive correlation between the two biomarkers. CONCLUSIONS: Survivin and VEGF-C are highly expressed in breast cancer tissues with a positive correlation. The regulation of survivin expression can cause excessive expression of VEGF-C, leading to the generation of breast cancer lymphangiogenesis, thus causing lymphatic metastasis of breast cancer.
PURPOSE: To study the expression of survivin and VEGF-C in breast cancer tissue and its relation to lymphatic metastasis. METHODS: The expression level of survivin and VEGF-C in breast cancer tissue is determined by immunohistochemistry and reverse transcriptase polymerase chain reaction (Rt-PCR). RESULTS: Among the 60 breast cancer tissues, the percentage of positive expression of survivin or VEGF-C was 85.0% and 78.3%, respectively. The expression rate of VEGF-C was 84.3% (43/51), 44.4% (4/9) in the survivin positive and negative expression group, respectively. Linear correlation analysis showed a correlation coefficient of survivin and VEGF-C in breast cancer was 0.80 (p = 0.035), which indicates a positive correlation between the two biomarkers. CONCLUSIONS: Survivin and VEGF-C are highly expressed in breast cancer tissues with a positive correlation. The regulation of survivin expression can cause excessive expression of VEGF-C, leading to the generation of breast cancer lymphangiogenesis, thus causing lymphatic metastasis of breast cancer.
Authors: S M Cheng; Y C Chang; C Y Liu; J Y C Lee; H H Chan; C W Kuo; K Y Lin; S L Tsai; S H Chen; C F Li; E Leung; J R Kanwar; C C Huang; J Y Chang; C H A Cheung Journal: Br J Pharmacol Date: 2014-12-01 Impact factor: 9.473