Literature DB >> 22585914

Maternal dietary DHA supplementation to improve inflammatory outcomes in the preterm infant.

Christina J Valentine1.   

Abstract

Dietary DHA (22:6n-3) is a long-chain PUFA that has provocative effects on inflammatory signal events that could potentially affect preterm infant health. It is well known that the essential fatty acid of the (n-3) series; α-linolenic acid (18:3n:3) can be desaturated and elongated in the liver endoplasmic reticulum and peroxisome to produce the 22-carbon DHA. Nevertheless, concern exists as to the efficiency of this mechanism in providing the preterm infant with adequate DHA. Activity of the δ-6-desaturase and the δ-5-desaturase necessary for DHA synthesis is decreased by protein deprivation. The combined effects of suboptimal intake of both DHA and protein in the preterm infants could have substantial clinical consequences.

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Year:  2012        PMID: 22585914      PMCID: PMC3649472          DOI: 10.3945/an.111.001248

Source DB:  PubMed          Journal:  Adv Nutr        ISSN: 2161-8313            Impact factor:   8.701


  87 in total

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Authors:  Lynette K Rogers; Christina J Valentine; Michael Pennell; Markus Velten; Rodney D Britt; Kelly Dingess; Xuilan Zhao; Stephen E Welty; Trent E Tipple
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5.  Assessment of DHA on reducing early preterm birth: the ADORE randomized controlled trial protocol.

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