| Literature DB >> 22585914 |
Abstract
Dietary DHA (22:6n-3) is a long-chain PUFA that has provocative effects on inflammatory signal events that could potentially affect preterm infant health. It is well known that the essential fatty acid of the (n-3) series; α-linolenic acid (18:3n:3) can be desaturated and elongated in the liver endoplasmic reticulum and peroxisome to produce the 22-carbon DHA. Nevertheless, concern exists as to the efficiency of this mechanism in providing the preterm infant with adequate DHA. Activity of the δ-6-desaturase and the δ-5-desaturase necessary for DHA synthesis is decreased by protein deprivation. The combined effects of suboptimal intake of both DHA and protein in the preterm infants could have substantial clinical consequences.Entities:
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Year: 2012 PMID: 22585914 PMCID: PMC3649472 DOI: 10.3945/an.111.001248
Source DB: PubMed Journal: Adv Nutr ISSN: 2161-8313 Impact factor: 8.701