PURPOSE: To investigate the image quality and radiation dose of low radiation dose CT coronary angiography (CTCA) using sinogram affirmed iterative reconstruction (SAFIRE) compared with standard dose CTCA using filtered back-projection (FBP) in obese patients. MATERIALS AND METHODS:Seventy-eight consecutive obese patients were randomized into two groups and scanned using a prospectively ECG-triggered step-and-shot (SAS) CTCA protocol on a dual-source CT scanner. Thirty-nine patients (protocol A) were examined using a routine radiation dose protocol at 120 kV and images were reconstructed with FBP (protocol A). Thirty-nine patients (protocol B) were examined using a low dose protocol at 100 kV and images were reconstructed with SAFIRE. Two blinded observers independently assessed the image quality of each coronary segment using a 4-point scale (1=non-diagnostic, 4=excellent) and measured the objective parameters image noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR). Radiation dose was calculated. RESULTS: The coronary artery image quality scores, image noise, SNR and CNR were not significantly different between protocols A and B (all p>0.05), with image quality scores of 3.51±0.70 versus 3.55±0.47, respectively. The effective radiation dose was significantly lower in protocol B (4.41±0.83 mSv) than that in protocol A (8.83±1.74 mSv, p<0.01). CONCLUSION: Compared with standard dose CTCA using FBP, low dose CTCA using SAFIRE can maintain diagnostic image quality with 50% reduction of radiation dose.
RCT Entities:
PURPOSE: To investigate the image quality and radiation dose of low radiation dose CT coronary angiography (CTCA) using sinogram affirmed iterative reconstruction (SAFIRE) compared with standard dose CTCA using filtered back-projection (FBP) in obesepatients. MATERIALS AND METHODS: Seventy-eight consecutive obesepatients were randomized into two groups and scanned using a prospectively ECG-triggered step-and-shot (SAS) CTCA protocol on a dual-source CT scanner. Thirty-nine patients (protocol A) were examined using a routine radiation dose protocol at 120 kV and images were reconstructed with FBP (protocol A). Thirty-nine patients (protocol B) were examined using a low dose protocol at 100 kV and images were reconstructed with SAFIRE. Two blinded observers independently assessed the image quality of each coronary segment using a 4-point scale (1=non-diagnostic, 4=excellent) and measured the objective parameters image noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR). Radiation dose was calculated. RESULTS: The coronary artery image quality scores, image noise, SNR and CNR were not significantly different between protocols A and B (all p>0.05), with image quality scores of 3.51±0.70 versus 3.55±0.47, respectively. The effective radiation dose was significantly lower in protocol B (4.41±0.83 mSv) than that in protocol A (8.83±1.74 mSv, p<0.01). CONCLUSION: Compared with standard dose CTCA using FBP, low dose CTCA using SAFIRE can maintain diagnostic image quality with 50% reduction of radiation dose.
Authors: Annemarie M Den Harder; Martin J Willemink; Quirina M B De Ruiter; Pim A De Jong; Arnold M R Schilham; Gabriel P Krestin; Tim Leiner; Ricardo P J Budde Journal: Br J Radiol Date: 2015-11-12 Impact factor: 3.039
Authors: Stefanie Mangold; Julian L Wichmann; U Joseph Schoepf; Zachary B Poole; Christian Canstein; Akos Varga-Szemes; Damiano Caruso; Fabian Bamberg; Konstantin Nikolaou; Carlo N De Cecco Journal: Eur Radiol Date: 2016-02-04 Impact factor: 5.315
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