OBJECTIVES: We assessed the impact of wasting on survival in patients with tuberculosis by using a precise height-normalized lean tissue mass index (LMI) estimated by bioelectrical impedance analysis and body mass index (BMI). METHODS: In a retrospective cohort study, 747 adult pulmonary patients with tuberculosis who were screened for HIV and nutritional status were followed for survival. RESULTS: Of 747 patients, 310 had baseline wasting by BMI (kg/m(2)) and 103 by LMI (kg/m(2)). Total deaths were 105. Among men with reduced BMI, risk of death was 70% greater (hazard ratio [HR] 1.7, 95% confidence interval [95% CI] 1.03-2.81) than in men with normal BMI. Survival did not differ by LMI among men (HR 1.1; 95% CI 0.5-2.9). In women, both the BMI and LMI were associated with survival. Among women with reduced BMI, risk of death was 80% greater (HR 1.8; 95% CI 0.9-3.5) than in women with normal BMI; risk of death was 5-fold greater (HR 5.0; 95% CI 1.6-15.9) for women with low LMI compared with women with normal LMI. CONCLUSIONS: Wasting assessed by reduced BMI is associated with an increased risk for death among both men and women whereas reduced LMI is among women with tuberculosis.
OBJECTIVES: We assessed the impact of wasting on survival in patients with tuberculosis by using a precise height-normalized lean tissue mass index (LMI) estimated by bioelectrical impedance analysis and body mass index (BMI). METHODS: In a retrospective cohort study, 747 adult pulmonary patients with tuberculosis who were screened for HIV and nutritional status were followed for survival. RESULTS: Of 747 patients, 310 had baseline wasting by BMI (kg/m(2)) and 103 by LMI (kg/m(2)). Total deaths were 105. Among men with reduced BMI, risk of death was 70% greater (hazard ratio [HR] 1.7, 95% confidence interval [95% CI] 1.03-2.81) than in men with normal BMI. Survival did not differ by LMI among men (HR 1.1; 95% CI 0.5-2.9). In women, both the BMI and LMI were associated with survival. Among women with reduced BMI, risk of death was 80% greater (HR 1.8; 95% CI 0.9-3.5) than in women with normal BMI; risk of death was 5-fold greater (HR 5.0; 95% CI 1.6-15.9) for women with low LMI compared with women with normal LMI. CONCLUSIONS: Wasting assessed by reduced BMI is associated with an increased risk for death among both men and women whereas reduced LMI is among women with tuberculosis.
Authors: Ezekiel Mupere; Sarah Zalwango; Allan Chiunda; Alphonse Okwera; Roy Mugerwa; Christopher Whalen Journal: Ann Epidemiol Date: 2010-03 Impact factor: 3.797
Authors: Carole Mitnick; Jaime Bayona; Eda Palacios; Sonya Shin; Jennifer Furin; Felix Alcántara; Epifanio Sánchez; Madeleny Sarria; Mercedes Becerra; Mary C Smith Fawzi; Saidi Kapiga; Donna Neuberg; James H Maguire; Jim Yong Kim; Paul Farmer Journal: N Engl J Med Date: 2003-01-09 Impact factor: 91.245
Authors: Christopher C Whalen; Sarah Zalwango; Allan Chiunda; LaShaunda Malone; Kathleen Eisenach; Moses Joloba; W Henry Boom; Roy Mugerwa Journal: PLoS One Date: 2011-02-14 Impact factor: 3.240
Authors: Catherine M Stein; Sarah Zalwango; LaShaunda L Malone; Bonnie Thiel; Ezekiel Mupere; Mary Nsereko; Brenda Okware; Hussein Kisingo; Christina L Lancioni; Charles M Bark; Christopher C Whalen; Moses L Joloba; W Henry Boom; Harriet Mayanja-Kizza Journal: Am J Epidemiol Date: 2018-07-01 Impact factor: 4.897
Authors: M Bakari; J Wamsele; T MacKenzie; I Maro; J Kimario; S Ali; S Dowla; K Hendricks; Z Lukmanji; N M Neke; R Waddell; M Matee; K Pallangyo; C F von Reyn Journal: Public Health Action Date: 2013-09-21
Authors: Amara E Ezeamama; Ezekiel Mupere; James Oloya; Leonardo Martinez; Robert Kakaire; Xiaoping Yin; Juliet N Sekandi; Christopher C Whalen Journal: Int J Infect Dis Date: 2015-04-21 Impact factor: 3.623
Authors: G PrayGod; M Blevins; S Woodd; A M Rehman; K Jeremiah; H Friis; P Kelly; J Changalucha; D C Heimburger; S Filteau; J R Koethe Journal: Eur J Clin Nutr Date: 2016-01-20 Impact factor: 4.016
Authors: Ezekiel Mupere; LaShaunda Malone; Sarah Zalwango; Alphonse Okwera; Mary Nsereko; Daniel J Tisch; Isabel M Parraga; Catherine M Stein; Roy Mugerwa; W Henry Boom; Harriet K Mayanja; Christopher C Whalen Journal: BMC Infect Dis Date: 2014-01-13 Impact factor: 3.090
Authors: Melissa R Nyendak; Byung Park; Megan D Null; Joy Baseke; Gwendolyn Swarbrick; Harriet Mayanja-Kizza; Mary Nsereko; Denise F Johnson; Phineas Gitta; Alphonse Okwera; Stefan Goldberg; Lorna Bozeman; John L Johnson; W Henry Boom; Deborah A Lewinsohn; David M Lewinsohn Journal: PLoS One Date: 2013-12-04 Impact factor: 3.240