Jingwei He1, Eva Söderling, Lippo V J Lassila, Pekka K Vallittu. 1. Department of Biomaterials Science, Institute of Dentistry and Biocity Turku Biomaterial Research Program, University of Turku, Turku 20520, Finland. hejin@utu.fi
Abstract
OBJECTIVES: The purpose of this study was to prepare antibacterial and radiopaque dental resin through adding one polymerizable quaternary ammonium compound with iodine as counter anion into Bis-GMA/TEGDMA (50/50, wt/wt) dental resin system, and evaluate the degree of monomer conversion, mechanical properties, radiopacity, and antibacterial effectiveness of the polymer. METHODS: 2-Dimethyl-2-dodecyl-1-methacryloxyethyl ammonium iodine (DDMAI) (3 wt.% and 5 wt.%) was added into a Bis-GMA/TEGDMA (50/50, wt/wt) resin system with CQ (0.7 wt.%) and DMAEMA (0.7 wt.%) as photoinitiation system. Degree of monomer conversion (DC) was determined by FT-IR analysis. The flexural strength (FS) and flexural modulus (FM) of the polymer were measured using a three-point bending set up. Radiographs were taken to determine the radiopacity of the polymer, and aluminum step-wedge (0.5-4mm) was used as calibration standard. A single-species biofilm model with Streptococcus mutans as the tests organism was used to evaluate the antibacterial property of the polymer. Bis-GMA/TEGDMA without DDMAI was used as control material in all of the tests. RESULTS: ANOVA analysis revealed that there was no significant difference in DC between polymer with and without DDMAI (p>0.05). Polymer with 3 wt.% DDMAI had higher FS than the control material (p<0.05), while polymer with 5 wt.% DDMAI had comparable FS with the control material (p>0.05). Though average FM of control material was lower than that of 3 wt.% DDMAI containing polymer and higher than 5 wt.% DDMAI containing polymer, but the differences were statistically insignificant. By increasing the quantity of DDMAI, the radiopacity of the polymer increased. Of the three formulations, the polymer with 5 wt.% DDMAI inhibited biofilm the formation of the clinically relevant young biofilm. SIGNIFICANCE: Incorporation of DDMAI into resin system could endow it with radiopacity and antibacterial effectiveness, and these two properties seem to be improved with increasing the quantities of DDMAI.
OBJECTIVES: The purpose of this study was to prepare antibacterial and radiopaque dental resin through adding one polymerizable quaternary ammonium compound with iodine as counter anion into Bis-GMA/TEGDMA (50/50, wt/wt) dental resin system, and evaluate the degree of monomer conversion, mechanical properties, radiopacity, and antibacterial effectiveness of the polymer. METHODS:2-Dimethyl-2-dodecyl-1-methacryloxyethyl ammonium iodine (DDMAI) (3 wt.% and 5 wt.%) was added into a Bis-GMA/TEGDMA (50/50, wt/wt) resin system with CQ (0.7 wt.%) and DMAEMA (0.7 wt.%) as photoinitiation system. Degree of monomer conversion (DC) was determined by FT-IR analysis. The flexural strength (FS) and flexural modulus (FM) of the polymer were measured using a three-point bending set up. Radiographs were taken to determine the radiopacity of the polymer, and aluminum step-wedge (0.5-4mm) was used as calibration standard. A single-species biofilm model with Streptococcus mutans as the tests organism was used to evaluate the antibacterial property of the polymer. Bis-GMA/TEGDMA without DDMAI was used as control material in all of the tests. RESULTS: ANOVA analysis revealed that there was no significant difference in DC between polymer with and without DDMAI (p>0.05). Polymer with 3 wt.% DDMAI had higher FS than the control material (p<0.05), while polymer with 5 wt.% DDMAI had comparable FS with the control material (p>0.05). Though average FM of control material was lower than that of 3 wt.% DDMAI containing polymer and higher than 5 wt.% DDMAI containing polymer, but the differences were statistically insignificant. By increasing the quantity of DDMAI, the radiopacity of the polymer increased. Of the three formulations, the polymer with 5 wt.% DDMAI inhibited biofilm the formation of the clinically relevant young biofilm. SIGNIFICANCE: Incorporation of DDMAI into resin system could endow it with radiopacity and antibacterial effectiveness, and these two properties seem to be improved with increasing the quantities of DDMAI.
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