Literature DB >> 22570132

Clinical trials: new opportunities.

Sandra Bond Chapman1, Carl W Cotman, Howard M Fillit, Michela Gallagher, Christopher H van Dyck.   

Abstract

Human cognitive aging has been too long neglected and underappreciated for its critical importance to quality of life in old age. The articles in this session present novel approaches to improving cognitive function in normal aging persons with drugs and interventions that are based on findings in epidemiology, studies in aged animals, and in vitro research. In addition, since aging is the primary risk factor for Alzheimer's disease, these studies also have implications as interventions for prevention and treatment. As a field of research, new knowledge regarding the causes and mechanisms of cognitive aging are ripe for translation into human studies, with the application of this knowledge leading the development of interventions and therapeutics for the prevention of cognitive decline in old age and Alzheimer's disease.

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Year:  2012        PMID: 22570132      PMCID: PMC3708514          DOI: 10.1093/gerona/gls126

Source DB:  PubMed          Journal:  J Gerontol A Biol Sci Med Sci        ISSN: 1079-5006            Impact factor:   6.053


  41 in total

1.  Improving memory performance in the aged through mnemonic training: a meta-analytic study.

Authors:  P Verhaeghen; A Marcoen; L Goossens
Journal:  Psychol Aging       Date:  1992-06

2.  Declining executive control in normal aging predicts change in functional status: the Freedom House Study.

Authors:  Donald R Royall; Raymond Palmer; Laura K Chiodo; Marsha J Polk
Journal:  J Am Geriatr Soc       Date:  2004-03       Impact factor: 5.562

3.  BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog.

Authors:  Margaret Fahnestock; Monica Marchese; Elizabeth Head; Viorela Pop; Bernadeta Michalski; William N Milgram; Carl W Cotman
Journal:  Neurobiol Aging       Date:  2010-05-05       Impact factor: 4.673

4.  The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection.

Authors:  J E Ware; C D Sherbourne
Journal:  Med Care       Date:  1992-06       Impact factor: 2.983

5.  The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes.

Authors:  A F Arnsten; J X Cai; P S Goldman-Rakic
Journal:  J Neurosci       Date:  1988-11       Impact factor: 6.167

Review 6.  Structural changes that occur during normal aging of primate cerebral hemispheres.

Authors:  Alan Peters
Journal:  Neurosci Biobehav Rev       Date:  2002-11       Impact factor: 8.989

7.  Behavioral and receptor binding analysis of the alpha 2-adrenergic agonist, 5-bromo-6 [2-imidazoline-2-yl amino] quinoxaline (UK-14304): evidence for cognitive enhancement at an alpha 2-adrenoceptor subtype.

Authors:  A F Arnsten; F M Leslie
Journal:  Neuropharmacology       Date:  1991-12       Impact factor: 5.250

8.  Prevalence of cognitive impairment: data from the Indianapolis Study of Health and Aging.

Authors:  F W Unverzagt; S Gao; O Baiyewu; A O Ogunniyi; O Gureje; A Perkins; C L Emsley; J Dickens; R Evans; B Musick; K S Hall; S L Hui; H C Hendrie
Journal:  Neurology       Date:  2001-11-13       Impact factor: 9.910

9.  Cambridge Neuropsychological Test Automated Battery (CANTAB): a factor analytic study of a large sample of normal elderly volunteers.

Authors:  T W Robbins; M James; A M Owen; B J Sahakian; L McInnes; P Rabbitt
Journal:  Dementia       Date:  1994 Sep-Oct

10.  Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline.

Authors:  Brian P Ramos; Shari G Birnbaum; Isabelle Lindenmayer; Samuel S Newton; Ronald S Duman; Amy F T Arnsten
Journal:  Neuron       Date:  2003-11-13       Impact factor: 17.173

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  2 in total

Review 1.  Molecular aspects of age-related cognitive decline: the role of GABA signaling.

Authors:  Joseph A McQuail; Charles J Frazier; Jennifer L Bizon
Journal:  Trends Mol Med       Date:  2015-06-09       Impact factor: 11.951

2.  Nutraceutical intervention improves older adults' cognitive functioning.

Authors:  Brent J Small; Kerri S Rawson; Christina Martin; Sarah L Eisel; Cyndy D Sanberg; Cathy L McEvoy; Paul R Sanberg; R Douglas Shytle; Jun Tan; Paula C Bickford
Journal:  Rejuvenation Res       Date:  2014-02       Impact factor: 4.663

  2 in total

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