BACKGROUND AND PURPOSE:Repetitive transcranial magnetic stimulation (rTMS) may enhance plastic changes in the human cortex and modulation of behavior. However, the underlying neural mechanisms have not been sufficiently investigated. We examined the clinical effects and neural correlates of high-frequency rTMS coupled with motor training in patients with hemiparesis after stroke. METHODS:Twenty-one patients were randomly divided into two groups, and received either real or sham rTMS. Ten daily sessions of 1,000 pulses of real or sham rTMS were applied at 10 Hz over the primary motor cortex of the affected hemisphere, coupled with sequential finger motor training of the paretic hand. Functional MRIs were obtained before and after training using sequential finger motor tasks, and performances were assessed. RESULTS: Following rTMS intervention, movement accuracy of sequential finger motor tasks showed significantly greater improvement in the real group than in the sham group (p < 0.05). Real rTMS modulated areas of brain activation during performance of motor tasks with a significant interaction effect in the sensorimotor cortex, thalamus, and caudate nucleus. Patients in the real rTMS group also showed significantly enhanced activation in the affected hemisphere compared to the sham rTMS group. CONCLUSION: According to these results, a 10 day course of high-frequency rTMS coupled with motor training improved motor performance through modulation of activities in the cortico-basal ganglia-thalamocortical circuits.
RCT Entities:
BACKGROUND AND PURPOSE: Repetitive transcranial magnetic stimulation (rTMS) may enhance plastic changes in the human cortex and modulation of behavior. However, the underlying neural mechanisms have not been sufficiently investigated. We examined the clinical effects and neural correlates of high-frequency rTMS coupled with motor training in patients with hemiparesis after stroke. METHODS: Twenty-one patients were randomly divided into two groups, and received either real or sham rTMS. Ten daily sessions of 1,000 pulses of real or sham rTMS were applied at 10 Hz over the primary motor cortex of the affected hemisphere, coupled with sequential finger motor training of the paretic hand. Functional MRIs were obtained before and after training using sequential finger motor tasks, and performances were assessed. RESULTS: Following rTMS intervention, movement accuracy of sequential finger motor tasks showed significantly greater improvement in the real group than in the sham group (p < 0.05). Real rTMS modulated areas of brain activation during performance of motor tasks with a significant interaction effect in the sensorimotor cortex, thalamus, and caudate nucleus. Patients in the real rTMS group also showed significantly enhanced activation in the affected hemisphere compared to the sham rTMS group. CONCLUSION: According to these results, a 10 day course of high-frequency rTMS coupled with motor training improved motor performance through modulation of activities in the cortico-basal ganglia-thalamocortical circuits.
Authors: H R Siebner; M Peller; F Willoch; S Minoshima; H Boecker; C Auer; A Drzezga; B Conrad; P Bartenstein Journal: Neurology Date: 2000-02-22 Impact factor: 9.910
Authors: Nick S Ward; Jennifer M Newton; Orlando B C Swayne; Lucy Lee; Richard S J Frackowiak; Alan J Thompson; Richard J Greenwood; John C Rothwell Journal: Eur J Neurosci Date: 2007-03 Impact factor: 3.386
Authors: James R Carey; Diane M Chappuis; Marsha J Finkelstein; Kate L Frost; Lynette K Leuty; Allison L McNulty; Lars I E Oddsson; Erin M Seifert; Teresa J Kimberley Journal: Phys Ther Date: 2017-03-01
Authors: Giovanni Di Pino; Giovanni Pellegrino; Giovanni Assenza; Fioravante Capone; Florinda Ferreri; Domenico Formica; Federico Ranieri; Mario Tombini; Ulf Ziemann; John C Rothwell; Vincenzo Di Lazzaro Journal: Nat Rev Neurol Date: 2014-09-09 Impact factor: 42.937
Authors: Kelsey A Potter-Baker; Corin E Bonnett; Patrick Chabra; Sarah Roelle; Nicole Varnerin; David A Cunningham; Vishwanath Sankarasubramanian; Svetlana Pundik; Adriana B Conforto; Andre G Machado; Ela B Plow Journal: J Stroke Cerebrovasc Dis Date: 2016-02-02 Impact factor: 2.136
Authors: Shalini Narayana; Wei Zhang; William Rogers; Casey Strickland; Crystal Franklin; Jack L Lancaster; Peter T Fox Journal: Neuroimage Date: 2013-07-15 Impact factor: 6.556
Authors: David A Cunningham; Kelsey A Potter-Baker; Jayme S Knutson; Vishwanath Sankarasubramanian; Andre G Machado; Ela B Plow Journal: Phys Med Rehabil Clin N Am Date: 2015-09-09 Impact factor: 1.784