Literature DB >> 22528206

Membrane-based continuous remover of trifluoroacetic acid in mobile phase for LC-ESI-MS analysis of small molecules and proteins.

Zhigui Zhou1, Jialing Zhang, Jiawei Xing, Yu Bai, Yiping Liao, Huwei Liu.   

Abstract

We developed a "continuous" trifluoroacetic acid (TFA) remover based on electrodialysis with bipolar membrane for online coupling of liquid chromatography (LC) and electrospray ionization mass spectrometry (ESI-MS) using TFA containing mobile phase. With the TFA remover as an interface, the TFA anion in the mobile phase was removed based on electrodialysis mechanism, and meanwhile, the anion exchange membrane was self-regenerated by the hydroxide ions produced by the bipolar membrane. So the remover could continuously work without any additional regeneration process. The established LC-TFA remover-MS system has been successfully applied for the qualitative and quantitative analysis of small molecules as well as proteins.

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Year:  2012        PMID： 22528206     DOI： 10.1007/s13361-012-0385-z

Source DB:  PubMed          Journal:  J Am Soc Mass Spectrom        ISSN： 1044-0305            Impact factor:   3.109


  7 in total

1.  Preliminary investigation of the application of on-line membrane extraction of trifluoroacetic acid as an aid to improvement of negative ion electrospray mass spectrometry data.

Authors:  A P New; J C Wolff; S Crabtree; L Freitas do Santos; G Okafo; J Lee; K Divan
Journal:  J Chromatogr A       Date:  2001-04-13       Impact factor: 4.759

2.  Effect of ion-exchange nanofiber fabrics on water splitting in bipolar membrane.

Authors:  Yuji Wakamatsu; Hidetoshi Matsumoto; Mie Minagawa; Akihiko Tanioka
Journal:  J Colloid Interface Sci       Date:  2006-04-27       Impact factor: 8.128

3.  Simple means to alleviate sensitivity loss by trifluoroacetic acid (TFA) mobile phases in the hydrophilic interaction chromatography-electrospray tandem mass spectrometric (HILIC-ESI/MS/MS) bioanalysis of basic compounds.

Authors:  Wilson Z Shou; Weng Naidong
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2005-10-25       Impact factor: 3.205

4.  Signal enhancement for peptide analysis in liquid chromatography-electrospray ionization mass spectrometry with trifluoroacetic acid containing mobile phase by postcolumn electrophoretic mobility control.

Authors:  Nan-Hsuan Wang; Wan-Li Lee; Guor-Rong Her
Journal:  Anal Chem       Date:  2011-07-22       Impact factor: 6.986

5.  Factors affecting electrospray ionization of effluents containing trifluoroacetic acid for high-performance liquid chromatography/mass spectrometry.

Authors:  J Eshraghi; S K Chowdhury
Journal:  Anal Chem       Date:  1993-12-01       Impact factor: 6.986

6.  Signal enhancement for gradient reverse-phase high-performance liquid chromatography-electrospray ionization mass spectrometry analysis with trifluoroacetic and other strong acid modifiers by postcolumn addition of propionic acid and isopropanol.

Authors:  F E Kuhlmann; A Apffel; S M Fischer; G Goldberg; P C Goodley
Journal:  J Am Soc Mass Spectrom       Date:  1995-12       Impact factor: 3.109

7.  Enhanced sensitivity for peptide mapping with electrospray liquid chromatography-mass spectrometry in the presence of signal suppression due to trifluoroacetic acid-containing mobile phases.

Authors:  A Apffel; S Fischer; G Goldberg; P C Goodley; F E Kuhlmann
Journal:  J Chromatogr A       Date:  1995-09-29       Impact factor: 4.759
  7 in total
  1 in total

1.  Microfluidic ion stripper for removal of trifluoroacetic acid from mobile phases used in HILIC-MS of intact proteins.

Authors:  Sam Wouters; Sebastiaan Eeltink; Rob Haselberg; Govert W Somsen; Andrea F G Gargano
Journal:  Anal Bioanal Chem       Date:  2021-05-28       Impact factor: 4.142
  1 in total

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