Literature DB >> 22522509

Mechanisms of age-related cognitive change and targets for intervention: epigenetics.

Kenneth S Kosik1, Peter R Rapp, Naftali Raz, Scott A Small, J David Sweatt, Li-Huei Tsai.   

Abstract

Epigenetic regulation of gene expression plays an important role in learning and memory, mediating the influence of experience on critical mechanisms of plasticity. Speakers in the opening session of the Summit reviewed research on epigenetic contributions to age-related cognitive decline and discussed strategies for the development of interventions targeting epigenetic mechanisms. The presentations focused on experience-dependent DNA methylation, the regulatory role of microRNAs, histone deacetylases as potential therapeutic targets, and strategies for exploring epigenetic contributions to the aging of brain and cognition. This session established useful mileposts for gaging progress in this rapidly advancing area of research.

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Year:  2012        PMID： 22522509      PMCID： PMC4009730          DOI： 10.1093/gerona/gls110

Source DB:  PubMed          Journal:  J Gerontol A Biol Sci Med Sci        ISSN： 1079-5006            Impact factor:   6.053


  45 in total

1.  Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging.

Authors:  Scott A Small; Monica K Chawla; Michael Buonocore; Peter R Rapp; Carol A Barnes
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-26       Impact factor: 11.205

2.  Regulation of histone acetylation during memory formation in the hippocampus.

Authors:  Jonathan M Levenson; Kenneth J O'Riordan; Karen D Brown; Mimi A Trinh; David L Molfese; J David Sweatt
Journal:  J Biol Chem       Date:  2004-07-23       Impact factor: 5.157

3.  An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus.

Authors:  Ana C Pereira; Dan E Huddleston; Adam M Brickman; Alexander A Sosunov; Rene Hen; Guy M McKhann; Richard Sloan; Fred H Gage; Truman R Brown; Scott A Small
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-20       Impact factor: 11.205

4.  Covalent modification of DNA regulates memory formation.

Authors:  Courtney A Miller; J David Sweatt
Journal:  Neuron       Date:  2007-03-15       Impact factor: 17.173

5.  Visual object pattern separation deficits in nondemented older adults.

Authors:  Chelsea K Toner; Eva Pirogovsky; C Brock Kirwan; Paul E Gilbert
Journal:  Learn Mem       Date:  2009-04-29       Impact factor: 2.460

6.  Ink4a/Arf regulation by let-7b and Hmga2: a genetic pathway governing stem cell aging.

Authors:  Alexandros Tzatsos; Nabeel Bardeesy
Journal:  Cell Stem Cell       Date:  2008-11-06       Impact factor: 24.633

7.  Histone deacetylase inhibitors and neurodegenerative disorders: holding the promise.

Authors:  Antonello Mai; Dante Rotili; Sergio Valente; Aleksey G Kazantsev
Journal:  Curr Pharm Des       Date:  2009       Impact factor: 3.116

Review 8.  Histone deacetylases (HDACs): characterization of the classical HDAC family.

Authors:  Annemieke J M de Ruijter; Albert H van Gennip; Huib N Caron; Stephan Kemp; André B P van Kuilenburg
Journal:  Biochem J       Date:  2003-03-15       Impact factor: 3.857

9.  Rapid and selective induction of BDNF expression in the hippocampus during contextual learning.

Authors:  J Hall; K L Thomas; B J Everitt
Journal:  Nat Neurosci       Date:  2000-06       Impact factor: 24.884

10.  HDAC2 negatively regulates memory formation and synaptic plasticity.

Authors:  Ji-Song Guan; Stephen J Haggarty; Emanuela Giacometti; Jan-Hermen Dannenberg; Nadine Joseph; Jun Gao; Thomas J F Nieland; Ying Zhou; Xinyu Wang; Ralph Mazitschek; James E Bradner; Ronald A DePinho; Rudolf Jaenisch; Li-Huei Tsai
Journal:  Nature       Date:  2009-05-07       Impact factor: 49.962
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  24 in total

1.  Accelerated reduction of serum thyroxine and hippocampal histone acetylation links to exacerbation of spatial memory impairment in aged CD-1 mice pubertally exposed to bisphenol-a.

Authors:  Wei Jiang; Lei Cao; Fang Wang; Hai Ge; Peng-Chao Wu; Xue-Wei Li; Gui-Hai Chen
Journal:  Age (Dordr)       Date:  2016-09-09

Review 2.  Folate and epigenetic mechanisms in neural tube development and defects.

Authors:  Sivan Vadakkadath Meethal; Kirk J Hogan; Chandra S Mayanil; Bermans J Iskandar
Journal:  Childs Nerv Syst       Date:  2013-09-07       Impact factor: 1.475

3.  Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.

Authors:  Zoltan Ungvari; Zsuzsanna Tucsek; Danuta Sosnowska; Peter Toth; Tripti Gautam; Andrej Podlutsky; Agnes Csiszar; Gyorgy Losonczy; M Noa Valcarcel-Ares; William E Sonntag; Anna Csiszar
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-12-13       Impact factor: 6.053

4.  Histone modifications change with age, dietary restriction and rapamycin treatment in mouse brain.

Authors:  Huan Gong; Hong Qian; Robin Ertl; Clinton M Astle; Gang G Wang; David E Harrison; Xiangru Xu
Journal:  Oncotarget       Date:  2015-06-30

5.  Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.

Authors:  Anna Csiszar; Danuta Sosnowska; Zsuzsanna Tucsek; Tripti Gautam; Peter Toth; Gyorgy Losonczy; Ricki J Colman; Richard Weindruch; Rozalyn M Anderson; William E Sonntag; Zoltan Ungvari
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2012-08-17       Impact factor: 6.053

6.  Noradrenaline goes nuclear: epigenetic modifications during long-lasting synaptic potentiation triggered by activation of β-adrenergic receptors.

Authors:  Sabyasachi Maity; Timothy J Jarome; Jessica Blair; Farah D Lubin; Peter V Nguyen
Journal:  J Physiol       Date:  2015-12-21       Impact factor: 5.182

7.  Age-related changes in Egr1 transcription and DNA methylation within the hippocampus.

Authors:  M R Penner; R R Parrish; L T Hoang; T L Roth; F D Lubin; C A Barnes
Journal:  Hippocampus       Date:  2016-04-04       Impact factor: 3.899

8.  Three midlife strategies to prevent cognitive impairment due to Alzheimer's disease.

Authors:  V W Henderson
Journal:  Climacteric       Date:  2014-08-17       Impact factor: 3.005

Review 9.  Genetics of cognition in epilepsy.

Authors:  Robyn M Busch; Imad Najm; Bruce P Hermann; Charis Eng
Journal:  Epilepsy Behav       Date:  2014-06-25       Impact factor: 2.937

10.  Differential patterns of gray matter volumes and associated gene expression profiles in cognitively-defined Alzheimer's disease subgroups.

Authors:  Colin Groot; Michel J Grothe; Shubhabrata Mukherjee; Irina Jelistratova; Iris Jansen; Anna Catharina van Loenhoud; Shannon L Risacher; Andrew J Saykin; Christine L Mac Donald; Jesse Mez; Emily H Trittschuh; Gregor Gryglewski; Rupert Lanzenberger; Yolande A L Pijnenburg; Frederik Barkhof; Philip Scheltens; Wiesje M van der Flier; Paul K Crane; Rik Ossenkoppele
Journal:  Neuroimage Clin       Date:  2021-04-03       Impact factor: 4.881
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