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Literature DB >> 18983959

Ink4a/Arf regulation by let-7b and Hmga2: a genetic pathway governing stem cell aging.

Abstract

Stem cell self-renewal capacity declines with age. In a recent issue of Cell, Nishino and colleagues (2008) show that Hmga2 maintains neural stem cell (NSC) function in young mice through repression of the Ink4a/Arf locus; in contrast, during aging, elevated let-7b blocks Hmga2 and contributes to declining NSC function.

Entities: Disease Gene Species

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Year: 2008 PMID： 18983959 DOI： 10.1016/j.stem.2008.10.008

Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633

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Cited

21 in total

Review 1. Mechanisms of age-related cognitive change and targets for intervention: epigenetics.

Authors: Kenneth S Kosik; Peter R Rapp; Naftali Raz; Scott A Small; J David Sweatt; Li-Huei Tsai
Journal: J Gerontol A Biol Sci Med Sci Date: 2012-04-20 Impact factor: 6.053

2. Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells.

Authors: Alexandros Tzatsos; Polina Paskaleva; Stephania Lymperi; Gianmarco Contino; Svetlana Stoykova; Zhao Chen; Kwok-Kin Wong; Nabeel Bardeesy
Journal: J Biol Chem Date: 2011-07-11 Impact factor: 5.157

Ink4a/Arf regulation by let-7b and Hmga2: a genetic pathway governing stem cell aging.

Review 1. Mechanisms of age-related cognitive change and targets for intervention: epigenetics.

2. Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells.

3. HMGA2 overexpression-induced ovarian surface epithelial transformation is mediated through regulation of EMT genes.

4. HMGA2 protein expression in ovarian serous carcinoma effusions, primary tumors, and solid metastases.

Review 5. Role of MicroRNA Let-7 in Modulating Multifactorial Aspect of Neurodegenerative Diseases: an Overview.

6. Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a.

7. EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling.

8. Probing into the biological processes influenced by ESC factor and oncoprotein HMGA2 using iPSCs.

9. The Expression and Significance of the Plasma Let-7 Family in Anti-N-methyl-D-aspartate Receptor Encephalitis.

10. Transcriptome profiling identifies HMGA2 as a biomarker of melanoma progression and prognosis.