Literature DB >> 22508303

In vitro susceptibility of Pythium insidiosum isolates to aminoglycoside antibiotics and tigecycline.

Deise Luiza Mahl1, Francielli Pantella Kunz de Jesus, Érico Silva Loreto, Régis Adriel Zanette, Laerte Ferreiro, Maiara Ben Pilotto, Sydney Hartz Alves, Janio Morais Santurio.   

Abstract

This study evaluated the in vitro activity of aminoglycoside antibiotics and tigecycline against Pythium insidiosum. The susceptibility tests were carried out using the broth microdilution method in accordance with the CLSI document M38-A2. MIC values for gentamicin, neomycin, paromomycin, and streptomycin ranged from 32 to 64 mg/liter, and the minimal fungicidal concentration (MFC) ranged from 32 to 128 mg/liter, which are incompatible with safe concentrations of these drugs in plasma in vivo. Tigecycline showed the lowest MIC (0.25 to 2 mg/liter) and MFC (1 to 8 mg/liter) range values. The in vitro susceptibility observed to tigecycline makes this drug a good option in future tests in vitro and in vivo for the management of pythiosis.

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Year:  2012        PMID： 22508303      PMCID： PMC3393386          DOI： 10.1128/AAC.00073-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

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2.  The effect of chloramphenicol on growth and mitochondrial structure of Pythium ultimum.

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3.  Molecular diagnosis of subcutaneous Pythium insidiosum infection by use of PCR screening and DNA sequencing.

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4.  A meta-analysis of the relative efficacy and toxicity of single daily dosing versus multiple daily dosing of aminoglycosides.

Authors:  M Z Ali; M B Goetz
Journal:  Clin Infect Dis       Date:  1997-05       Impact factor: 9.079

5.  In vitro susceptibility of Pythium insidiosum to macrolides and tetracycline antibiotics.

Authors:  Erico Silva Loreto; Débora Alves Nunes Mario; Laura Bedin Denardi; Sydney Hartz Alves; Janio Morais Santurio
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6.  Activity of some aminoglycoside antibiotics against true fungi, Phytophthora and Pythium species.

Authors:  H B Lee; Y Kim; J C Kim; G J Choi; S-H Park; C-J Kim; H S Jung
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  10 in total
  11 in total

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Journal:  Antimicrob Agents Chemother       Date:  2018-02-23       Impact factor: 5.191

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Authors:  Marina Y Fosso; Yijia Li; Sylvie Garneau-Tsodikova
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Journal:  Antimicrob Agents Chemother       Date:  2014-07-07       Impact factor: 5.191

4.  New insights into the in vitro susceptibility of Pythium insidiosum.

Authors:  Erico S Loreto; Juliana S M Tondolo; Maiara B Pilotto; Sydney H Alves; Janio M Santurio
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5.  In Vitro Susceptibility of Thai Pythium insidiosum Isolates to Antibacterial Agents.

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Journal:  Antimicrob Agents Chemother       Date:  2020-03-24       Impact factor: 5.191

6.  In vitro susceptibility of Brazilian Pythium insidiosum isolates to essential oils of some Lamiaceae family species.

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9.  In Vitro and In Vivo Antimicrobial Activities of Minocycline in Combination with Azithromycin, Clarithromycin, or Tigecycline against Pythium insidiosum.

Authors:  Francielli P K Jesus; Érico S Loreto; Laerte Ferreiro; Sydney H Alves; David Driemeier; Suyene O Souza; Raqueli T França; Sonia T A Lopes; Maiara B Pilotto; Aline Ludwig; Maria I Azevedo; Tatiana C Ribeiro; Juliana S M Tondolo; Janio M Santurio
Journal:  Antimicrob Agents Chemother       Date:  2015-10-12       Impact factor: 5.191

Review 10.  Review of methods and antimicrobial agents for susceptibility testing against Pythium insidiosum.

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Journal:  Heliyon       Date:  2020-04-12
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