| Literature DB >> 22495435 |
Sarah K Volkman1, Daniel E Neafsey, Stephen F Schaffner, Daniel J Park, Dyann F Wirth.
Abstract
Malaria is an important human disease and is the target of a global eradication campaign. New technological and informatics advancements in population genomics are being leveraged to identify genetic loci under selection in the malaria parasite and to find variants that are associated with key clinical phenotypes, such as drug resistance. This article provides a timely Review of how population-genetics-based strategies are being applied to Plasmodium falciparum both to identify genetic loci as key targets of interventions and to develop monitoring and surveillance tools that are crucial for the successful elimination and eradication of malaria.Entities:
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Year: 2012 PMID： 22495435 DOI： 10.1038/nrg3187
Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242