Literature DB >> 27185795

Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal.

Mathieu Gendrot1, Bécaye Fall2, Marylin Madamet3, Mansour Fall4, Khalifa Ababacar Wade5, Rémy Amalvict3, Aminata Nakoulima6, Nicolas Benoit3, Silman Diawara2, Yaya Diémé2, Bakary Diatta7, Boubacar Wade8, Bruno Pradines9.   

Abstract

The RING E3 ubiquitin protein ligase is crucial for facilitating the transfer of ubiquitin. The only polymorphism identified in the E3 ubiquitin protein ligase gene was the D113N mutation (62.5%) but was not significantly associated with the 50% inhibitory concentration (IC50) of conventional antimalarial drugs. However, some mutated isolates (D113N) present a trend of reduced susceptibility to piperaquine (P = 0.0938). To evaluate the association of D113N polymorphism with susceptibility to antimalarials, more isolates are necessary.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27185795      PMCID： PMC4958203          DOI： 10.1128/AAC.03105-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study.

Authors:  Michele D Spring; Jessica T Lin; Jessica E Manning; Pattaraporn Vanachayangkul; Sok Somethy; Rathvicheth Bun; Youry Se; Soklyda Chann; Mali Ittiverakul; Piyaporn Sia-ngam; Worachet Kuntawunginn; Montri Arsanok; Nillawan Buathong; Suwanna Chaorattanakawee; Panita Gosi; Winita Ta-aksorn; Nitima Chanarat; Siratchana Sundrakes; Nareth Kong; Thay Kheang Heng; Samon Nou; Paktiya Teja-isavadharm; Sathit Pichyangkul; Sut Thang Phann; Sujata Balasubramanian; Jonathan J Juliano; Steven R Meshnick; Char Meng Chour; Satharath Prom; Charlotte A Lanteri; Chanthap Lon; David L Saunders
Journal:  Lancet Infect Dis       Date:  2015-04-12       Impact factor: 25.071

Review 2.  The ubiquitin system.

Authors:  A Hershko; A Ciechanover
Journal:  Annu Rev Biochem       Date:  1998       Impact factor: 23.643

Review 3.  The ubiquitin system: an essential component to unlocking the secrets of malaria parasite biology.

Authors:  Michael J Hamilton; Michael Lee; Karine G Le Roch
Journal:  Mol Biosyst       Date:  2014-01-30

4.  Artemisinin resistance in Plasmodium falciparum malaria.

Authors:  Arjen M Dondorp; François Nosten; Poravuth Yi; Debashish Das; Aung Phae Phyo; Joel Tarning; Khin Maung Lwin; Frederic Ariey; Warunee Hanpithakpong; Sue J Lee; Pascal Ringwald; Kamolrat Silamut; Mallika Imwong; Kesinee Chotivanich; Pharath Lim; Trent Herdman; Sen Sam An; Shunmay Yeung; Pratap Singhasivanon; Nicholas P J Day; Niklas Lindegardh; Duong Socheat; Nicholas J White
Journal:  N Engl J Med       Date:  2009-07-30       Impact factor: 91.245

5.  Spread of artemisinin resistance in Plasmodium falciparum malaria.

Authors:  Elizabeth A Ashley; Mehul Dhorda; Rick M Fairhurst; Chanaki Amaratunga; Parath Lim; Seila Suon; Sokunthea Sreng; Jennifer M Anderson; Sivanna Mao; Baramey Sam; Chantha Sopha; Char Meng Chuor; Chea Nguon; Siv Sovannaroth; Sasithon Pukrittayakamee; Podjanee Jittamala; Kesinee Chotivanich; Kitipumi Chutasmit; Chaiyaporn Suchatsoonthorn; Ratchadaporn Runcharoen; Tran Tinh Hien; Nguyen Thanh Thuy-Nhien; Ngo Viet Thanh; Nguyen Hoan Phu; Ye Htut; Kay-Thwe Han; Kyin Hla Aye; Olugbenga A Mokuolu; Rasaq R Olaosebikan; Olaleke O Folaranmi; Mayfong Mayxay; Maniphone Khanthavong; Bouasy Hongvanthong; Paul N Newton; Marie A Onyamboko; Caterina I Fanello; Antoinette K Tshefu; Neelima Mishra; Neena Valecha; Aung Pyae Phyo; Francois Nosten; Poravuth Yi; Rupam Tripura; Steffen Borrmann; Mahfudh Bashraheil; Judy Peshu; M Abul Faiz; Aniruddha Ghose; M Amir Hossain; Rasheda Samad; M Ridwanur Rahman; M Mahtabuddin Hasan; Akhterul Islam; Olivo Miotto; Roberto Amato; Bronwyn MacInnis; Jim Stalker; Dominic P Kwiatkowski; Zbynek Bozdech; Atthanee Jeeyapant; Phaik Yeong Cheah; Tharisara Sakulthaew; Jeremy Chalk; Benjamas Intharabut; Kamolrat Silamut; Sue J Lee; Benchawan Vihokhern; Chanon Kunasol; Mallika Imwong; Joel Tarning; Walter J Taylor; Shunmay Yeung; Charles J Woodrow; Jennifer A Flegg; Debashish Das; Jeffery Smith; Meera Venkatesan; Christopher V Plowe; Kasia Stepniewska; Philippe J Guerin; Arjen M Dondorp; Nicholas P Day; Nicholas J White
Journal:  N Engl J Med       Date:  2014-07-31       Impact factor: 91.245

6.  Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment.

Authors:  Rithea Leang; Walter R J Taylor; Denis Mey Bouth; Lijiang Song; Joel Tarning; Meng Chuor Char; Saorin Kim; Benoit Witkowski; Valentine Duru; Anais Domergue; Nimol Khim; Pascal Ringwald; Didier Menard
Journal:  Antimicrob Agents Chemother       Date:  2015-05-26       Impact factor: 5.191

7.  Ex vivo susceptibility of Plasmodium falciparum isolates from Dakar, Senegal, to seven standard anti-malarial drugs.

Authors:  Bécaye Fall; Silmane Diawara; Kowry Sow; Eric Baret; Bakary Diatta; Khadidiatou B Fall; Pape S Mbaye; Fatou Fall; Yaya Diémé; Christophe Rogier; Boubacar Wade; Raymond Bercion; Bruno Pradines
Journal:  Malar J       Date:  2011-10-20       Impact factor: 2.979

8.  Multinormal in vitro distribution of Plasmodium falciparum susceptibility to piperaquine and pyronaridine.

Authors:  Aurélie Pascual; Marilyn Madamet; Sébastien Briolant; Tiphaine Gaillard; Rémy Amalvict; Nicolas Benoit; Dominique Travers; Bruno Pradines
Journal:  Malar J       Date:  2015-02-05       Impact factor: 2.979

9.  Plasmodium falciparum susceptibility to standard and potential anti-malarial drugs in Dakar, Senegal, during the 2013-2014 malaria season.

Authors:  Bécaye Fall; Cheikhou Camara; Mansour Fall; Aminata Nakoulima; Pierre Dionne; Bakary Diatta; Yaya Diemé; Boubacar Wade; Bruno Pradines
Journal:  Malar J       Date:  2015-02-06       Impact factor: 2.979

10.  A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum.

Authors:  Cecilia P Sanchez; Chia-Hao Liu; Sybille Mayer; Astutiati Nurhasanah; Marek Cyrklaff; Jianbing Mu; Michael T Ferdig; Wilfred D Stein; Michael Lanzer
Journal:  PLoS Genet       Date:  2014-05-15       Impact factor: 5.917
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  5 in total

1.  Baseline Ex Vivo and Molecular Responses of Plasmodium falciparum Isolates to Piperaquine before Implementation of Dihydroartemisinin-Piperaquine in Senegal.

Authors:  Marie Gladys Robert; Francis Foguim Tsombeng; Mathieu Gendrot; Silman Diawara; Marylin Madamet; Mame Bou Kounta; Khalifa Ababacar Wade; Mansour Fall; Mamadou Wague Gueye; Nicolas Benoit; Aminata Nakoulima; Raymond Bercion; Rémy Amalvict; Bécaye Fall; Boubacar Wade; Bakary Diatta; Bruno Pradines
Journal:  Antimicrob Agents Chemother       Date:  2019-04-25       Impact factor: 5.191

2.  The D113N mutation in the RING E3 ubiquitin protein ligase gene is not associated with ex vivo susceptibility to common anti-malarial drugs in African Plasmodium falciparum isolates.

Authors:  Mathieu Gendrot; Francis Tsombeng Foguim; Marie Gladys Robert; Rémy Amalvict; Joel Mosnier; Nicolas Benoit; Marylin Madamet; Bruno Pradines
Journal:  Malar J       Date:  2018-03-12       Impact factor: 2.979

3.  Malaria, tuberculosis and HIV: what's new? Contribution of the Institut Hospitalo-Universitaire Méditerranée Infection in updated data.

Authors:  Lionel Almeras; Leonardo K Basco; Cheikh Sokhna; Stéphane Ranque; Philippe Parola; Christian Devaux; Philippe Brouqui; Michel Drancourt; Bruno Pradines
Journal:  New Microbes New Infect       Date:  2018-07-04

4.  Are k13 and plasmepsin II genes, involved in Plasmodium falciparum resistance to artemisinin derivatives and piperaquine in Southeast Asia, reliable to monitor resistance surveillance in Africa?

Authors:  Francis Foguim Tsombeng; Mathieu Gendrot; Marie Gladys Robert; Marylin Madamet; Bruno Pradines
Journal:  Malar J       Date:  2019-08-23       Impact factor: 2.979

5.  Absence of Association between Methylene Blue Reduced Susceptibility and Polymorphisms in 12 Genes Involved in Antimalarial Drug Resistance in African Plasmodium falciparum.

Authors:  Mathieu Gendrot; Océane Delandre; Marie Gladys Robert; Francis Tsombeng Foguim; Nicolas Benoit; Rémy Amalvict; Isabelle Fonta; Joel Mosnier; Marylin Madamet; Bruno Pradines; On Behalf Of The French National Reference Centre For Imported Malaria Study Group
Journal:  Pharmaceuticals (Basel)       Date:  2021-04-09
  5 in total

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