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Literature DB >> 22482367

Peptidolipins B-F, antibacterial lipopeptides from an ascidian-derived Nocardia sp.

Thomas P Wyche¹, Yanpeng Hou, Emmanuel Vazquez-Rivera, Doug Braun, Tim S Bugni.

Abstract

A marine Nocardia sp. isolated from the ascidian Trididemnum orbiculatum was found to produce five new lipopeptides, peptidolipins B-F (1-5), which show distinct similarities to the previously reported L-Val(6) analog of peptidolipin NA. Synthetic modification of peptidolipin E (4) was used to determine the location of an olefin within the lipid chain. The advanced Marfey's method was used to determine the absolute configurations of the amino acids. Peptidolipins B (1) and E (4) demonstrated moderate antibacterial activity against methicillin-resistant Staphylococcus aureus and methicillin-sensitive Staphylococcus aureus.

Entities: CellLine Chemical Disease Species

Mesh：

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Year: 2012 PMID： 22482367 PMCID： PMC3349995 DOI： 10.1021/np300016r

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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16 in total

1. Application of 3D NMR for Structure Determination of Peptide Natural Products.

Authors: Fan Zhang; Navid Adnani; Emmanuel Vazquez-Rivera; Doug R Braun; Marco Tonelli; David R Andes; Tim S Bugni
Journal: J Org Chem Date: 2015-08-21 Impact factor: 4.354

2. Thalassosamide, a Siderophore Discovered from the Marine-Derived Bacterium Thalassospira profundimaris.

Authors: Fan Zhang; Kenneth Barns; F Michael Hoffmann; Doug R Braun; David R Andes; Tim S Bugni
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Authors: Rushikesh Sable; Pravin Parajuli; Seetharama Jois
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