| Literature DB >> 12760678 |
Wenying Li1, John E Leet, Helen A Ax, Donald R Gustavson, Daniel M Brown, Laura Turner, Kimberly Brown, Junius Clark, Hyekyung Yang, Joan Fung-Tomc, Kin S Lam.
Abstract
Thiazolyl peptide antibiotics, nocathiacin I, II and III, were identified in a culture of Nocardia sp. WW-12651 (ATCC 202099). They exhibit potent in vitro activity (ng/ml) against a wide spectrum of gram-positive bacteria, including multiple-drug resistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA), multi-drug resistant Enterococcus faecium (MREF) and fully penicillin-resistant Streptococcus pneumoniae (PRSP), and demonstrate excellent in vivo efficacy in a systemic Staphylococcus aureus infection mice model.Entities:
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Year: 2003 PMID： 12760678 DOI： 10.7164/antibiotics.56.226
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649