Literature DB >> 22476953

Buyers beware: lead poisoning due to Ayurvedic medicine.

J Matthew R Pierce1, Carlos A Estrada, Ronnie E Mathews.   

Abstract

A 29-year-old man, who recently emigrated from India, presented with a 2-week history of abdominal pain, as well as nausea, constipation, and fatigue. He underwent removal of a parathyroid adenoma 6 weeks prior to admission and received a locally made Indian traditional medicine (Ayurveda) for pain control; however, this information was not initially available. He was instructed to take approximately 15 g/day. Initial evaluation revealed a normocytic anemia, but other workup including imaging and endoscopy was unrevealing. Given his recent use of Ayurvedic medicines, we tested for lead poisoning and found a blood lead level of 72 mcg/dl. We sent his medicine for analysis and found it had a high lead concentration of 36,000 mcg/g, which is over 25,000 times the maximum daily dose. He improved with cessation of the medicine and treatment with succimer. Lead poisoning can present with a variety of nonspecific signs and symptoms, including abdominal pain and anemia. Ayurvedic medicines, as well as traditional medicines from other cultures, may be a source of lead or other heavy metals. It is essential for physicians to be aware of adverse effects of Ayurvedic medicines as they are easily available and increasing in popularity.

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Year:  2012        PMID: 22476953      PMCID: PMC3445671          DOI: 10.1007/s11606-012-2048-y

Source DB:  PubMed          Journal:  J Gen Intern Med        ISSN: 0884-8734            Impact factor:   5.128


  9 in total

Review 1.  The use and safety of non-allopathic Indian medicines.

Authors:  N J Gogtay; H A Bhatt; S S Dalvi; N A Kshirsagar
Journal:  Drug Saf       Date:  2002       Impact factor: 5.606

2.  Heavy metal content of ayurvedic herbal medicine products.

Authors:  Robert B Saper; Stefanos N Kales; Janet Paquin; Michael J Burns; David M Eisenberg; Roger B Davis; Russell S Phillips
Journal:  JAMA       Date:  2004-12-15       Impact factor: 56.272

3.  Adult blood lead epidemiology and surveillance--United States, 2008-2009.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2011-07-01       Impact factor: 17.586

Review 4.  Dimercaptosuccinic acid (succimer; DMSA) in inorganic lead poisoning.

Authors:  Sally Bradberry; Allister Vale
Journal:  Clin Toxicol (Phila)       Date:  2009-08       Impact factor: 4.467

5.  Hematopoietic toxicity from lead-containing Ayurvedic medications.

Authors:  Stefanos N Kales; Costas A Christophi; Robert B Saper
Journal:  Med Sci Monit       Date:  2007-07

6.  Complementary and alternative medicine use among adults and children: United States, 2007.

Authors:  Patricia M Barnes; Barbara Bloom; Richard L Nahin
Journal:  Natl Health Stat Report       Date:  2008-12-10

7.  Lead, mercury, and arsenic in US- and Indian-manufactured Ayurvedic medicines sold via the Internet.

Authors:  Robert B Saper; Russell S Phillips; Anusha Sehgal; Nadia Khouri; Roger B Davis; Janet Paquin; Venkatesh Thuppil; Stefanos N Kales
Journal:  JAMA       Date:  2008-08-27       Impact factor: 56.272

8.  Ayurvedic lead poisoning: an under-recognized, international problem.

Authors:  Stefanos N Kales; Robert B Saper
Journal:  Indian J Med Sci       Date:  2009-09

Review 9.  Recommendations for medical management of adult lead exposure.

Authors:  Michael J Kosnett; Richard P Wedeen; Stephen J Rothenberg; Karen L Hipkins; Barbara L Materna; Brian S Schwartz; Howard Hu; Alan Woolf
Journal:  Environ Health Perspect       Date:  2006-12-22       Impact factor: 9.031

  9 in total
  3 in total

1.  Toxic metals in ayurvedic preparations from a public health lead poisoning cluster investigation.

Authors:  Marek A Mikulski; Michael D Wichman; Donald L Simmons; Anthony N Pham; Valentina Clottey; Laurence J Fuortes
Journal:  Int J Occup Environ Health       Date:  2018-03-12

2.  Are Ayurvedic medications store house of heavy metals?

Authors:  A Bhalla; A K Pannu
Journal:  Toxicol Res (Camb)       Date:  2022-01-15       Impact factor: 3.524

3.  Case of acute lead toxicity associated with Ayurvedic supplements.

Authors:  Amelia Breyre; Judith Green-McKenzie
Journal:  BMJ Case Rep       Date:  2016-06-30
  3 in total

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