Literature DB >> 22470114

Stability of extemporaneously prepared 0.5-percent caspofungin eye drops: a potential cost-savings exercise.

Chin Fen Neoh1, Jovan Jacob, Lok Leung, Jian Li, Angela Stathopoulos, Kay Stewart, David C M Kong.   

Abstract

While the successful use of topical caspofungin for patients has been reported, topical caspofungin is not commercially available and its stability is unknown, limiting its usefulness in treating fungal keratitis. Caspofungin (0.5%) eye drops were aseptically prepared, and the concentrations were measured using a validated high-performance liquid chromatography (HPLC) analysis. The preparations remained stable for 28 days under refrigerated condition but not at 25.0 °C. Our study supports the cost-saving use of caspofungin eye drops in the clinical setting.

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Year:  2012        PMID： 22470114      PMCID： PMC3370802          DOI： 10.1128/AAC.00060-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  Successful topical application of caspofungin in the treatment of fungal keratitis refractory to voriconazole.

Authors:  Mercedes Hurtado-Sarrió; Antonio Duch-Samper; Angel Cisneros-Lanuza; Manuel Díaz-Llopis; Javier Peman-Garcíia; Amparo Vazquez-Polo
Journal:  Arch Ophthalmol       Date:  2010-07

2.  Topical caspofungin for treatment of keratitis caused by Candida albicans in a rabbit model.

Authors:  David Goldblum; Beatrice E Frueh; Gian-Marco Sarra; Konstantinos Katsoulis; Stefan Zimmerli
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

3.  Penetration of topically administered 0.5-percent caspofungin eye drops into human aqueous humor.

Authors:  Chin Fen Neoh; Lok Leung; Anant Misra; Rasik B Vajpayee; Geoffrey E Davies; Robert O Fullinfaw; Kay Stewart; David C M Kong
Journal:  Antimicrob Agents Chemother       Date:  2011-01-24       Impact factor: 5.191

4.  Treatment of Alternaria keratitis with intrastromal and topical caspofungin in combination with intrastromal, topical, and oral voriconazole.

Authors:  Chin Fen Neoh; Lok Leung; Rasik B Vajpayee; Kay Stewart; David C M Kong
Journal:  Ann Pharmacother       Date:  2011-04-26       Impact factor: 3.154

5.  Pharmacokinetics of caspofungin and voriconazole in critically ill patients during extracorporeal membrane oxygenation.

Authors:  Isabel Spriet; Pieter Annaert; Philippe Meersseman; Greet Hermans; Wouter Meersseman; Rene Verbesselt; Ludo Willems
Journal:  J Antimicrob Chemother       Date:  2009-02-13       Impact factor: 5.790

6.  Alternaria keratitis: clinical presentation and resolution with topical fluconazole or intrastromal voriconazole and topical caspofungin.

Authors:  Elmer Y Tu
Journal:  Cornea       Date:  2009-01       Impact factor: 2.651

7.  Fungal keratitis in Melbourne.

Authors:  Prashant Bhartiya; Mark Daniell; Marios Constantinou; F M Amirul Islam; Hugh R Taylor
Journal:  Clin Exp Ophthalmol       Date:  2007-03       Impact factor: 4.207

8.  Aqueous humor concentrations of topically administered caspofungin in rabbits.

Authors:  Christian K Vorwerk; S Tuchen; F Streit; L Binder; W Hofmüller; W Behrens-Baumann
Journal:  Ophthalmic Res       Date:  2008-12-20       Impact factor: 2.892

9.  Stability of cefazolin sodium eye drops.

Authors:  T H How; W Y Loo; K L Yow; L Y Lim; E W Chan; P C Ho; S Y Chan
Journal:  J Clin Pharm Ther       Date:  1998-02       Impact factor: 2.512

Review 10.  Medical interventions for fungal keratitis.

Authors:  N V Florcruz; I Peczon
Journal:  Cochrane Database Syst Rev       Date:  2008-01-23
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  1 in total

1.  Echinocandins Localized to the Target-Harboring Cell Surface Are Not Degraded but Those Entering the Vacuole Are.

Authors:  Qais Z Jaber; Dana Logviniuk; Adi Yona; Micha Fridman
Journal:  ACS Chem Biol       Date:  2022-04-11       Impact factor: 4.634
  1 in total

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