BACKGROUND/AIMS: This study gives insight into survival predictors and clinicopathological features of carcinoma of the gastric cardia. METHODOLOGY: The study included 233 patients who underwent operation for carcinoma of the gastric cardia. Clinicopathological prognostic variables were evaluated as predictors of long-term survival by univariate and multivariate analysis. Cox regression was used for multivariate analysis and survival curves were drawn by the Kaplan- Meier method. RESULTS: Carcinoma of the gastric cardia was characterized by positive lymph node metastasis (77.3%), serosal invasion (83.3%) and more stage III or IV tumors (72.5%). Overall 5-year survival rate was 21.9% and median survival period was 24 months. The 5-year survival rate was influenced by tumor size, depth on invasion, lymph node metastasis, extent of lymph node dissection, disease stage, operation methods and resection margin. CONCLUSIONS: The absent of serosal invasion and lymph node metastasis, curative resection should be considered to be the favourable predictors of long-term survival of patients with carcinoma of the gastric cardia.
BACKGROUND/AIMS: This study gives insight into survival predictors and clinicopathological features of carcinoma of the gastric cardia. METHODOLOGY: The study included 233 patients who underwent operation for carcinoma of the gastric cardia. Clinicopathological prognostic variables were evaluated as predictors of long-term survival by univariate and multivariate analysis. Cox regression was used for multivariate analysis and survival curves were drawn by the Kaplan- Meier method. RESULTS:Carcinoma of the gastric cardia was characterized by positive lymph node metastasis (77.3%), serosal invasion (83.3%) and more stage III or IV tumors (72.5%). Overall 5-year survival rate was 21.9% and median survival period was 24 months. The 5-year survival rate was influenced by tumor size, depth on invasion, lymph node metastasis, extent of lymph node dissection, disease stage, operation methods and resection margin. CONCLUSIONS: The absent of serosal invasion and lymph node metastasis, curative resection should be considered to be the favourable predictors of long-term survival of patients with carcinoma of the gastric cardia.
Authors: Jialing Zhang; John Rector; John Q Lin; Jonathan H Young; Marta Sans; Nitesh Katta; Noah Giese; Wendong Yu; Chandandeep Nagi; James Suliburk; Jinsong Liu; Alena Bensussan; Rachel J DeHoog; Kyana Y Garza; Benjamin Ludolph; Anna G Sorace; Anum Syed; Aydin Zahedivash; Thomas E Milner; Livia S Eberlin Journal: Sci Transl Med Date: 2017-09-06 Impact factor: 17.956
Authors: Livia S Eberlin; Robert J Tibshirani; Jialing Zhang; Teri A Longacre; Gerald J Berry; David B Bingham; Jeffrey A Norton; Richard N Zare; George A Poultsides Journal: Proc Natl Acad Sci U S A Date: 2014-02-03 Impact factor: 11.205
Authors: Livia S Eberlin; Katherine Margulis; Ivette Planell-Mendez; Richard N Zare; Robert Tibshirani; Teri A Longacre; Moe Jalali; Jeffrey A Norton; George A Poultsides Journal: PLoS Med Date: 2016-08-30 Impact factor: 11.069