| Literature DB >> 22461365 |
Eva-Marie Heinrich1, Stefanie Dimmeler.
Abstract
Stem cells hold great promise for regenerative medicine and the treatment of cardiovascular diseases. The mechanisms regulating self-renewal, pluripotency, and differentiation are not fully understood. MicroRNAs (miRs) are small noncoding RNAs controlling gene expression, either by inducing mRNA degradation or by blocking mRNA translation. The expression of miRs was shown to regulate various aspects of stem cell functions, including the maintenance and induction of pluripotency for reprogramming. In addition, some miRs control cell fate decisions. This review summarizes the role of miRs in reprogramming and embryonic stem cell self-renewal, and specifically addresses the regulation of cardiovascular cell fate decisions by miRs.Entities:
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Year: 2012 PMID: 22461365 DOI: 10.1161/CIRCRESAHA.111.243394
Source DB: PubMed Journal: Circ Res ISSN: 0009-7330 Impact factor: 17.367