BACKGROUND AND OBJECTIVES: Living donor paired exchange programs assume that kidneys from living donors are of comparable quality and anticipated longevity. This study determined actual allograft t(1/2) within different recipient age groups (10-year increments) as a function of donor age (5-year increments), and juxtaposed these results against the probabilities of deceased donor transplantation, and exclusion from transplantation (death or removal from the wait-list). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Data from the US Renal Data System (transplant dates 1988-2003 with follow-up through September 2007) were used to determine allograft t(1/2), whereas data from patients on the United Network for Organ Sharing waiting list between 2003 and 2005 (with follow-up through February 2010) were used to determine wait-list outcomes. RESULTS: With the exception of recipients aged 18-39 years, who had the best outcomes with donors aged 18-39 years, living donor age between 18 and 64 years had minimal effect on allograft t(1/2) (difference of 1-2 years with no graded association). The probability of deceased donor transplantation after 3 years of wait-listing ranged from 21% to 66% by blood type and level of sensitization, whereas the probability of being excluded from transplantation ranged from 6% to 27% by age, race, and primary renal disease. CONCLUSIONS: With the exception of recipients aged 18-39 years, living donor age between 18 and 64 years has minimal effect on allograft survival.
BACKGROUND AND OBJECTIVES: Living donor paired exchange programs assume that kidneys from living donors are of comparable quality and anticipated longevity. This study determined actual allograft t(1/2) within different recipient age groups (10-year increments) as a function of donor age (5-year increments), and juxtaposed these results against the probabilities of deceased donor transplantation, and exclusion from transplantation (death or removal from the wait-list). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Data from the US Renal Data System (transplant dates 1988-2003 with follow-up through September 2007) were used to determine allograft t(1/2), whereas data from patients on the United Network for Organ Sharing waiting list between 2003 and 2005 (with follow-up through February 2010) were used to determine wait-list outcomes. RESULTS: With the exception of recipients aged 18-39 years, who had the best outcomes with donors aged 18-39 years, living donor age between 18 and 64 years had minimal effect on allograft t(1/2) (difference of 1-2 years with no graded association). The probability of deceased donor transplantation after 3 years of wait-listing ranged from 21% to 66% by blood type and level of sensitization, whereas the probability of being excluded from transplantation ranged from 6% to 27% by age, race, and primary renal disease. CONCLUSIONS: With the exception of recipients aged 18-39 years, living donor age between 18 and 64 years has minimal effect on allograft survival.
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Authors: A Young; S J Kim; M R Speechley; A Huang; G A Knoll; G V Ramesh Prasad; D Treleaven; M Diamant; A X Garg Journal: Am J Transplant Date: 2011-03-14 Impact factor: 8.086
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Authors: M Abecassis; N D Bridges; C J Clancy; M A Dew; B Eldadah; M J Englesbe; M F Flessner; J C Frank; J Friedewald; J Gill; C Gries; J B Halter; E L Hartmann; W R Hazzard; F M Horne; J Hosenpud; P Jacobson; B L Kasiske; J Lake; R Loomba; P N Malani; T M Moore; A Murray; M-H Nguyen; N R Powe; P P Reese; H Reynolds; M D Samaniego; K E Schmader; D L Segev; A S Shah; L G Singer; J A Sosa; Z A Stewart; J C Tan; W W Williams; D W Zaas; K P High Journal: Am J Transplant Date: 2012-09-07 Impact factor: 8.086
Authors: Vivek B Kute; Manoj R Gumber; Himanshu V Patel; Pankaj R Shah; Aruna V Vanikar; Pranjal R Modi; Veena R Shah; Mohan P Patel; Hargovind L Trivedi Journal: Int Urol Nephrol Date: 2012-11-08 Impact factor: 2.370