| Literature DB >> 22431243 |
Miriam Colombo1, Serena Mazzucchelli, Josè Maria Montenegro, Elisabetta Galbiati, Fabio Corsi, Wolfgang J Parak, Davide Prosperi.
Abstract
A bimodular genetic fusion comprising a delivery module (scFv) and a capture module (SNAP) is proposed as a novel strategy for the site-specific covalent conjugation of targeting peptides to nanoparticles. An scFv mutant selective for HER2 tumor antigen is chosen as the targeting ligand. SNAP-scFv is immobilized on magnetofluorescent nanoparticles and its targeting efficiency against HER2-positive cells is assessed by flow cytometry and immunofluorescence.Entities:
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Year: 2012 PMID: 22431243 DOI: 10.1002/smll.201102284
Source DB: PubMed Journal: Small ISSN: 1613-6810 Impact factor: 13.281