| Literature DB >> 33650433 |
Carlos Sanchez-Cano1, Ramon A Alvarez-Puebla2,3, John M Abendroth4, Tobias Beck5, Robert Blick5, Yuan Cao6,7, Frank Caruso8, Indranath Chakraborty5, Henry N Chapman5,9,10, Chunying Chen11, Bruce E Cohen12, Andre L C Conceição10, David P Cormode13, Daxiang Cui14, Kenneth A Dawson15, Gerald Falkenberg10, Chunhai Fan14, Neus Feliu5,16, Mingyuan Gao17, Elisabetta Gargioni17, Claus-C Glüer18, Florian Grüner5,19, Moustapha Hassan20, Yong Hu21, Yalan Huang5, Samuel Huber17, Nils Huse5, Yanan Kang5, Ali Khademhosseini22, Thomas F Keller5,10, Christian Körnig5,19, Nicholas A Kotov6,7,23,24, Dorota Koziej5, Xing-Jie Liang11, Beibei Liu17, Sijin Liu25, Yang Liu5, Ziyao Liu5, Luis M Liz-Marzán1,26,27, Xiaowei Ma11, Andres Machicote17, Wolfgang Maison5, Adrian P Mancuso28,29, Saad Megahed5, Bert Nickel30, Ferdinand Otto5, Cristina Palencia5, Sakura Pascarelli28, Arwen Pearson5, Oula Peñate-Medina18, Bing Qi5, Joachim Rädler30, Joseph J Richardson8, Axel Rosenhahn17, Kai Rothkamm17, Michael Rübhausen5, Milan K Sanyal31, Raymond E Schaak32, Heinz-Peter Schlemmer33, Marius Schmidt34, Oliver Schmutzler5,19, Theo Schotten16, Florian Schulz5, A K Sood35, Kathryn M Spiers10, Theresa Staufer5,19, Dominik M Stemer36,37, Andreas Stierle5,10, Xing Sun5,38, Gohar Tsakanova39,40, Paul S Weiss36,37,41,42, Horst Weller5,16, Fabian Westermeier10, Ming Xu25, Huijie Yan5, Yuan Zeng5, Ying Zhao20, Yuliang Zhao11, Dingcheng Zhu5, Ying Zhu43,44, Wolfgang J Parak1,5,14.
Abstract
X-ray-based analytics are routinely applied in many fields, including physics, chemistry, materials science, and engineering. The full potential of such techniques in the life sciences and medicine, however, has not yet been fully exploited. We highlight current and upcoming advances in this direction. We describe different X-ray-based methodologies (including those performed at synchrotron light sources and X-ray free-electron lasers) and their potentials for application to investigate the nano-bio interface. The discussion is predominantly guided by asking how such methods could better help to understand and to improve nanoparticle-based drug delivery, though the concepts also apply to nano-bio interactions in general. We discuss current limitations and how they might be overcome, particularly for future use in vivo.Keywords: X-ray techniques; degradation; delivery; imaging; nanoparticles; nano−bio interface; spectroscopy; synchrotron radiation
Mesh：
Year: 2021 PMID： 33650433 PMCID： PMC7992135 DOI： 10.1021/acsnano.0c09563
Source DB: PubMed Journal: ACS Nano ISSN： 1936-0851 Impact factor: 15.881