Literature DB >> 22429436

A primary care specialist genetics service: a cluster-randomised factorial trial.

Greta Westwood1, Ruth Pickering, Sue Latter, Paul Little, Karen Gerard, Anneke Lucassen, I Karen Temple.   

Abstract

BACKGROUND: GPs do not have the confidence to identify patients at increased genetic risk. A specialist primary care clinical genetics service could support GPs with referral and provide local clinics for their patients. AIM: To test whether primary care genetic-led genetics education improves both non-cancer and cancer referral rates, and primary care-led genetics clinics improve the patient pathway. DESIGN AND
SETTING: Cluster-randomised factorial trial in 73 general practices in the south of England.
METHOD: Practices randomised to receive case scenario based seminar (intervention) or not (control), and referred patients a primary (intervention) or secondary (control) care genetic counsellor (GC)-led appointment. OUTCOME MEASURES: GP referral and clinic attendance rates (primary), appropriate cancer and case scenario referral rates, patient satisfaction, clinic costs, and case management (secondary).
RESULTS: Eighty-nine and 68 referrals made by 36 intervention and 37 control practices respectively. There was a trend towards an overall higher referral rate among educated GPs (referral rate ratio [RRR] 1.34, 95% confidence interval [CI] = 0.89 to 2.02; P = 0.161), and they made more appropriate cancer referrals (RRR 2.36, 95% CI = 1.07 to 5.24; P = 0.035). No indication of difference in clinic attendance rates (odds ratio 0.91, 95% CI = 0.43 to 1.95; P = 0.802) or patient satisfaction (P = 0.189). Patients spent 49% less travelling (£3.60 versus £6.62; P<0.001) and took 33% less time (39.7 versus 57.7 minutes; P<0.001) to attend a primary than secondary care appointment; 83% of GC-managed appointments met the 18-week referral to treatment, NHS target.
CONCLUSION: An integrated primary care genetics service both supports GPs in appropriate cancer referral and provides care in the right place by the right person.

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Mesh:

Year:  2012        PMID: 22429436      PMCID: PMC3289825          DOI: 10.3399/bjgp12X630089

Source DB:  PubMed          Journal:  Br J Gen Pract        ISSN: 0960-1643            Impact factor:   5.386


  24 in total

1.  GPs' views on their role in cancer genetics services and current practice.

Authors:  A Fry; H Campbell; H Gudmunsdottir; R Rush; M Porteous; D Gorman; A Cull
Journal:  Fam Pract       Date:  1999-10       Impact factor: 2.267

2.  Evaluation of the impact of two educational interventions on GP management of familial breast/ovarian cancer cases: a cluster randomised controlled trial.

Authors:  E Watson; A Clements; P Yudkin; P Rose; C Bukach; J Mackay; A Lucassen; J Austoker
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3.  Family history in primary care: understanding GPs' resistance to clinical genetics--qualitative study.

Authors:  Jonathan Mathers; Sheila Greenfield; Alison Metcalfe; Trevor Cole; Sarah Flanagan; Sue Wilson
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Review 4.  A model for the development of genetics education programs for health professionals.

Authors:  Clara L Gaff; MaryAnne Aitken; Anna Flouris; Sylvia A Metcalfe
Journal:  Genet Med       Date:  2007-07       Impact factor: 8.822

5.  A study of GP referrals to a family cancer clinic for breast/ovarian cancer.

Authors:  E Watson; J Austoker; A Lucassen
Journal:  Fam Pract       Date:  2001-04       Impact factor: 2.267

Review 6.  Internal and external validity of cluster randomised trials: systematic review of recent trials.

Authors:  Sandra Eldridge; Deborah Ashby; Catherine Bennett; Melanie Wakelin; Gene Feder
Journal:  BMJ       Date:  2008-03-25

Review 7.  Educational outreach visits: effects on professional practice and health care outcomes.

Authors:  M A O'Brien; S Rogers; G Jamtvedt; A D Oxman; J Odgaard-Jensen; D T Kristoffersen; L Forsetlund; D Bainbridge; N Freemantle; D A Davis; R B Haynes; E L Harvey
Journal:  Cochrane Database Syst Rev       Date:  2007-10-17

8.  Cancer genetics evaluation: barriers to and improvements for referral.

Authors:  Rachael Brandt; Zonera Ali; Allison Sabel; Terri McHugh; Paul Gilman
Journal:  Genet Test       Date:  2008-03

9.  Genetics education for health professionals: strategies and outcomes from a national initiative in the United Kingdom.

Authors:  Peter A Farndon; Catherine Bennett
Journal:  J Genet Couns       Date:  2008-02-05       Impact factor: 2.537

10.  Genetic educational needs and the role of genetics in primary care: a focus group study with multiple perspectives.

Authors:  Elisa Jf Houwink; Scheltus J van Luijk; Lidewij Henneman; Cees van der Vleuten; Geert Jan Dinant; Martina C Cornel
Journal:  BMC Fam Pract       Date:  2011-02-17       Impact factor: 2.497

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  6 in total

1.  Interventions to improve patient access to and utilisation of genetic and genomic counselling services.

Authors:  Caroline M Benjamin; Lois H Thomas; Heather Skirton; Shanna Gustafson; Jacqueline Coupe; Christine Patch; Rachel Belk; Svetlana Tishkovskaya; Kathleen Calzone; Katherine Payne
Journal:  Cochrane Database Syst Rev       Date:  2015-11-17

2.  Genomics in general practice: Generation Genome.

Authors:  Sarah C Hillman; Jeremy Dale
Journal:  Br J Gen Pract       Date:  2017-12       Impact factor: 5.386

3.  Genetic cancer risk assessment in general practice: systematic review of tools available, clinician attitudes, and patient outcomes.

Authors:  Will Rh Evans
Journal:  Br J Gen Pract       Date:  2019-04       Impact factor: 5.386

4.  Adopting clinical genomics: a systematic review of genomic literacy among physicians in cancer care.

Authors:  Vu T Dung Ha; Julie Frizzo-Barker; Peter Chow-White
Journal:  BMC Med Genomics       Date:  2018-02-13       Impact factor: 3.063

5.  The stepwise process of integrating a genetic counsellor into primary care.

Authors:  Caitlin Slomp; Emily Morris; Morgan Price; Alison M Elliott; Jehannine Austin
Journal:  Eur J Hum Genet       Date:  2022-01-31       Impact factor: 5.351

6.  The design, implementation, and effectiveness of intervention strategies aimed at improving genetic referral practices: a systematic review of the literature.

Authors:  April Morrow; Priscilla Chan; Katherine M Tucker; Natalie Taylor
Journal:  Genet Med       Date:  2021-08-24       Impact factor: 8.822

  6 in total

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