| Literature DB >> 22426745 |
Mariza Akemi Matsumoto1, Gustavo Caviquioli, Claudia Cristina Biguetti, Leandro de Andrade Holgado, Patrícia Pinto Saraiva, Ana Claudia Muniz Rennó, Roberto Yoshio Kawakami.
Abstract
Bioactive glasses represent an interesting class of bone substitute's biomaterials. The present study investigated the repair of bone defects filled with a novel bioactive vitroceramic (Biosilicate(®)), alone or in association with particulate autogenous bone grafts in calvaria defects of rabbits. After 7, 14, and 30 days the specimens were retrieved for histological, histomorphometric and immunohistochemistry analysis. Satisfactory bone formation was observed in all groups, and direct bone-biomaterial surface was noted. Histomorphometric assessment did not show statistically significant differences in bone formation among the groups and periods, except for BG group at day 14. Immunoexpression of Runx-2 was similar among the groups containing the graft and the biomaterial, being more intense than in control group. Similar result was observed for VEGF expression, especially in the last experimental period. These results revealed that Biosilicate(®) presented a favorable behavior, comparable to autogenous bone graft.Entities:
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Year: 2012 PMID: 22426745 DOI: 10.1007/s10856-012-4612-8
Source DB: PubMed Journal: J Mater Sci Mater Med ISSN: 0957-4530 Impact factor: 3.896