Literature DB >> 22426745

A novel bioactive vitroceramic presents similar biological responses as autogenous bone grafts.

Mariza Akemi Matsumoto1, Gustavo Caviquioli, Claudia Cristina Biguetti, Leandro de Andrade Holgado, Patrícia Pinto Saraiva, Ana Claudia Muniz Rennó, Roberto Yoshio Kawakami.   

Abstract

Bioactive glasses represent an interesting class of bone substitute's biomaterials. The present study investigated the repair of bone defects filled with a novel bioactive vitroceramic (Biosilicate(®)), alone or in association with particulate autogenous bone grafts in calvaria defects of rabbits. After 7, 14, and 30 days the specimens were retrieved for histological, histomorphometric and immunohistochemistry analysis. Satisfactory bone formation was observed in all groups, and direct bone-biomaterial surface was noted. Histomorphometric assessment did not show statistically significant differences in bone formation among the groups and periods, except for BG group at day 14. Immunoexpression of Runx-2 was similar among the groups containing the graft and the biomaterial, being more intense than in control group. Similar result was observed for VEGF expression, especially in the last experimental period. These results revealed that Biosilicate(®) presented a favorable behavior, comparable to autogenous bone graft.

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Year:  2012        PMID: 22426745     DOI: 10.1007/s10856-012-4612-8

Source DB:  PubMed          Journal:  J Mater Sci Mater Med        ISSN: 0957-4530            Impact factor:   3.896


  32 in total

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Review 4.  Maxillary autogenous bone grafting.

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9.  Immunoexpression of Cbfa-1/Runx2 and VEGF in sinus lift procedures using bone substitutes in rabbits.

Authors:  Leandro Soeiro De Souza Nunes; Renato Victor De Oliveira; Leandro Andrade Holgado; Hugo Nary Filho; Daniel Araki Ribeiro; Mariza Akemi Matsumoto
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5.  Sintered anorganic bone graft increases autocrine expression of VEGF, MMP-2 and MMP-9 during repair of critical-size bone defects.

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6.  Evaluation of Crystallized Biosilicate in the Reconstruction of Calvarial Defects.

Authors:  Marcelo Rodrigues Azenha; Suzie Aparecida de Lacerda; Heloísa Fonseca Marão; Oscar Peitl Filho; Osvaldo Magro Filho
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  9 in total

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