BACKGROUND: Bone marrow oedema (BMO) is included in MRI-based scoring systems of disease activity in adults with rheumatoid arthritis. Similar systems in juvenile idiopathic arthritis (JIA) are lacking. OBJECTIVE: To assess the reproducibility in a multi-centre setting of an MRI BMO scoring system in children with JIA. MATERIALS AND METHODS: Seventy-six wrist MRIs were read twice, independently, by two experienced paediatric radiologists. BMO was defined as ill-defined lesions within the trabecular bone, returning high and low signal on T2- and T1-weighted images respectively, with or without contrast enhancement. BMO extension was scored for each of 14 bones at the wrist from 0 (none) to 3 (extensive). RESULTS: The intra-observer agreement was moderate to excellent, with weighted kappa ranging from 0.85 to 1.0 and 0.49 to 1.0 (readers 1 and 2 respectively), while the inter-observer agreement ranged from 0.41 to 0.79. The intra- and inter-observer intraclass correlation coefficients were excellent and satisfactory, respectively. CONCLUSION: The scoring system was reliable and may be used for grading bone marrow abnormality in JIA. The relatively large variability in aggregate scores, particularly between readers, underscores the need for thorough standardisation.
BACKGROUND: Bone marrow oedema (BMO) is included in MRI-based scoring systems of disease activity in adults with rheumatoid arthritis. Similar systems in juvenile idiopathic arthritis (JIA) are lacking. OBJECTIVE: To assess the reproducibility in a multi-centre setting of an MRI BMO scoring system in children with JIA. MATERIALS AND METHODS: Seventy-six wrist MRIs were read twice, independently, by two experienced paediatric radiologists. BMO was defined as ill-defined lesions within the trabecular bone, returning high and low signal on T2- and T1-weighted images respectively, with or without contrast enhancement. BMO extension was scored for each of 14 bones at the wrist from 0 (none) to 3 (extensive). RESULTS: The intra-observer agreement was moderate to excellent, with weighted kappa ranging from 0.85 to 1.0 and 0.49 to 1.0 (readers 1 and 2 respectively), while the inter-observer agreement ranged from 0.41 to 0.79. The intra- and inter-observer intraclass correlation coefficients were excellent and satisfactory, respectively. CONCLUSION: The scoring system was reliable and may be used for grading bone marrow abnormality in JIA. The relatively large variability in aggregate scores, particularly between readers, underscores the need for thorough standardisation.
Authors: Marissa Lassere; Fiona McQueen; Mikkel Østergaard; Philip Conaghan; Ron Shnier; Charles Peterfy; Mette Klarlund; Paul Bird; Philip O'Connor; Neal Stewart; Paul Emery; Harry Genant; John Edmonds Journal: J Rheumatol Date: 2003-06 Impact factor: 4.666
Authors: Philip Conaghan; Marissa Lassere; Mikkel Østergaard; Charles Peterfy; Fiona McQueen; Philip O'Connor; Paul Bird; Bo Ejbjerg; Mette Klarlund; Ron Shnier; Harry Genant; Paul Emery; John Edmonds Journal: J Rheumatol Date: 2003-06 Impact factor: 4.666
Authors: Charles Peterfy; John Edmonds; Marissa Lassere; Philip Conaghan; Mikkel Østergaard; Fiona McQueen; Harry Genant; Mette Klarlund; Bo Ejbjerg; Neal Stewart; Paul Bird; Ron Shnier; Philip O'Connor; Paul Emery Journal: J Rheumatol Date: 2003-06 Impact factor: 4.666
Authors: Jasper F M M Rieter; Laura Tanturri de Horatio; Charlotte M Nusman; Lil-Sofie Ording Müller; Robert Hemke; Derk F M Avenarius; Marion A J van Rossum; Clara Malattia; Mario Maas; Karen Rosendahl Journal: Pediatr Radiol Date: 2016-07-12
Authors: Laura Tanturri de Horatio; Susan C Shelmerdine; Paola d'Angelo; Pier Luigi Di Paolo; Silvia Magni-Manzoni; Clara Malattia; Maria Beatrice Damasio; Paolo Tomà; Derk Avenarius; Karen Rosendahl Journal: Pediatr Radiol Date: 2022-09-23
Authors: Floris Verkuil; E Charlotte van Gulik; Charlotte M Nusman; Anouk M Barendregt; Amara Nassar-Sheikh Rashid; Dieneke Schonenberg-Meinema; Koert M Dolman; Mario Maas; Taco W Kuijpers; J Merlijn van den Berg; Robert Hemke Journal: Pediatr Radiol Date: 2020-07-13
Authors: Charlotte M Nusman; Robert Hemke; Marc A Benninga; Dieneke Schonenberg-Meinema; Angelika Kindermann; Marion A J van Rossum; J Merlijn van den Berg; Mario Maas; Taco W Kuijpers Journal: Eur Radiol Date: 2015-08-02 Impact factor: 5.315
Authors: Charlotte M Nusman; Laura Tanturri de Horatio; Robert Hemke; E Charlotte van Gulik; Lil-Sofie Ording Müller; Clara Malattia; Derk Avenarius; Paolo Toma; Johannes Roth; Nikolay Tzaribachev; Silvia Magni-Manzoni; Mario Maas; Andrea S Doria; Karen Rosendahl Journal: Pediatr Radiol Date: 2018-01-13