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Literature DB >> 22425741

Engineering humanized mice for improved hematopoietic reconstitution.

Adam C Drake¹, Qingfeng Chen, Jianzhu Chen.

Abstract

Humanized mice are immunodeficient animals engrafted with human hematopoietic stem cells that give rise to various lineages of human blood cells throughout the life of the mouse. This article reviews recent advances in the generation of humanized mice, focusing on practical considerations. We discuss features of different immunodeficient recipient mouse strains, sources of human hematopoietic stem cells, advances in expansion and genetic modification of hematopoietic stem cells, and techniques to modulate the cytokine environment of recipient mice, in order to enhance reconstitution of specific human blood lineage cells. We highlight the opportunities created by new technologies and discuss practical considerations on how to make best use of the widening array of basic models for specific research applications.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Cytokines

Year: 2012 PMID： 22425741 PMCID： PMC4081442 DOI： 10.1038/cmi.2012.6

Source DB: PubMed Journal: Cell Mol Immunol ISSN： 1672-7681 Impact factor: 11.530

90 in total

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Journal: Proc Natl Acad Sci U S A Date: 2005-07-25 Impact factor: 11.205

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Journal: Blood Date: 2005-05-26 Impact factor: 22.113

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Review 6. Experimental models to study development and function of the human immune system in vivo.

Authors: Nicolas Legrand; Kees Weijer; Hergen Spits
Journal: J Immunol Date: 2006-02-15 Impact factor: 5.422

7. Targeting platelet GPIbalpha transgene expression to human megakaryocytes and forming a complete complex with endogenous GPIbbeta and GPIX.

Authors: Q Shi; D A Wilcox; P A Morateck; S A Fahs; D Kenny; R R Montgomery
Journal: J Thromb Haemost Date: 2004-11 Impact factor: 5.824

8. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.

Authors: Leonard D Shultz; Bonnie L Lyons; Lisa M Burzenski; Bruce Gott; Xiaohua Chen; Stanley Chaleff; Malak Kotb; Stephen D Gillies; Marie King; Julie Mangada; Dale L Greiner; Rupert Handgretinger
Journal: J Immunol Date: 2005-05-15 Impact factor: 5.422

9. In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes.

Authors: Stephan Kissler; Patrick Stern; Kazue Takahashi; Kara Hunter; Laurence B Peterson; Linda S Wicker
Journal: Nat Genet Date: 2006-03-19 Impact factor: 38.330

10. Successful correction of the human beta-thalassemia major phenotype using a lentiviral vector.

Authors: Geetha Puthenveetil; Jessica Scholes; Denysha Carbonell; Naveen Qureshi; Ping Xia; Licheng Zeng; Shulian Li; Ying Yu; Alan L Hiti; Jiing-Kuan Yee; Punam Malik
Journal: Blood Date: 2004-08-03 Impact factor: 22.113

40 in total

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Review 2. Transcription factor-mediated reprogramming toward hematopoietic stem cells.

Authors: Wataru Ebina; Derrick J Rossi
Journal: EMBO J Date: 2015-02-20 Impact factor: 11.598

3. Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells.

Authors: Mark A DeWitt; Wendy Magis; Nicolas L Bray; Tianjiao Wang; Jennifer R Berman; Fabrizia Urbinati; Seok-Jin Heo; Therese Mitros; Denise P Muñoz; Dario Boffelli; Donald B Kohn; Mark C Walters; Dana Carroll; David I K Martin; Jacob E Corn
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Journal: Cell Mol Immunol Date: 2013-05-20 Impact factor: 11.530

Review 5. Humanized mice for immune system investigation: progress, promise and challenges.

Authors: Leonard D Shultz; Michael A Brehm; J Victor Garcia-Martinez; Dale L Greiner
Journal: Nat Rev Immunol Date: 2012-10-12 Impact factor: 53.106

Review 6. Interrogating open issues in cancer precision medicine with patient-derived xenografts.

Authors: Annette T Byrne; Denis G Alférez; Frédéric Amant; Daniela Annibali; Joaquín Arribas; Andrew V Biankin; Alejandra Bruna; Eva Budinská; Carlos Caldas; David K Chang; Robert B Clarke; Hans Clevers; George Coukos; Virginie Dangles-Marie; S Gail Eckhardt; Eva Gonzalez-Suarez; Els Hermans; Manuel Hidalgo; Monika A Jarzabek; Steven de Jong; Jos Jonkers; Kristel Kemper; Luisa Lanfrancone; Gunhild Mari Mælandsmo; Elisabetta Marangoni; Jean-Christophe Marine; Enzo Medico; Jens Henrik Norum; Héctor G Palmer; Daniel S Peeper; Pier Giuseppe Pelicci; Alejandro Piris-Gimenez; Sergio Roman-Roman; Oscar M Rueda; Joan Seoane; Violeta Serra; Laura Soucek; Dominique Vanhecke; Alberto Villanueva; Emilie Vinolo; Andrea Bertotti; Livio Trusolino
Journal: Nat Rev Cancer Date: 2017-01-20 Impact factor: 60.716

7. Cyclophosphamide Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcγR Expression.

Authors: Ali Roghanian; Guangan Hu; Christopher Fraser; Maneesh Singh; Russell B Foxall; Matthew J Meyer; Emma Lees; Heather Huet; Martin J Glennie; Stephen A Beers; Sean H Lim; Margaret Ashton-Key; Stephen M Thirdborough; Mark S Cragg; Jianzhu Chen
Journal: Cancer Immunol Res Date: 2019-08-26 Impact factor: 11.151