| Literature DB >> 22405760 |
Galen D Reed1, Peder E Z Larson, Cornelius von Morze, Robert Bok, Michael Lustig, Adam B Kerr, John M Pauly, John Kurhanewicz, Daniel B Vigneron.
Abstract
A rapid echo planar imaging sequence for dynamic imaging of [1-(13)C] lactate and [1-(13)C] pyruvate simultaneously was developed. Frequency-based separation of these metabolites was achieved by spatial shifting in the phase-encoded direction with the appropriate choice of echo spacing. Suppression of the pyruvate-hydrate and alanine resonances is achieved through an optimized spectral-spatial RF waveform. Signal sampling efficiency as a function of pyruvate and lactate excitation angle was simulated using two site exchange models. Dynamic imaging is demonstrated in a transgenic mouse model, and phantom validations of the RF pulse frequency selectivity were performed. Published by Elsevier Inc.Entities:
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Year: 2012 PMID： 22405760 PMCID： PMC3326401 DOI： 10.1016/j.jmr.2012.02.008
Source DB: PubMed Journal: J Magn Reson ISSN： 1090-7807 Impact factor: 2.229