Literature DB >> 22391532

Recurrent episodes of candidemia due to Candida glabrata with a mutation in hot spot 1 of the FKS2 gene developed after prolonged therapy with caspofungin.

María Teresa Durán-Valle1, Sara Gago, Alicia Gómez-López, Manuel Cuenca-Estrella, Leticia Jiménez Díez-Canseco, José Luis Gómez-Garcés, Oscar Zaragoza.   

Abstract

We report two episodes of recurrent candidemia caused by echinocandin-resistant Candida glabrata in a 69-year-old patient who underwent repeated abdominal surgery. In the first episode of candidemia, an echinocandin-susceptible Candida glabrata strain was isolated, and the patient was treated with caspofungin. The isolates from the later episodes showed resistance to echinocandins. Analysis of the HS1 region of the FKS2 gene showed the amino acid substitution S663P. Microsatellite analysis demonstrated a strong genetic relationship between the isolates.

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Year:  2012        PMID： 22391532      PMCID： PMC3370789          DOI： 10.1128/AAC.06100-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

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2.  Reduced Candida glabrata susceptibility secondary to an FKS1 mutation developed during candidemia treatment.

Authors:  John D Cleary; Guillermo Garcia-Effron; Stanley W Chapman; David S Perlin
Journal:  Antimicrob Agents Chemother       Date:  2008-03-31       Impact factor: 5.191

Review 3.  Resistance to echinocandin-class antifungal drugs.

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5.  FKS2 mutations associated with decreased echinocandin susceptibility of Candida glabrata following anidulafungin therapy.

Authors:  Sofia Costa-de-Oliveira; Isabel Marcos Miranda; Raquel M Silva; Ana Pinto E Silva; Rita Rocha; António Amorim; Acácio Gonçalves Rodrigues; Cidália Pina-Vaz
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6.  Development of caspofungin resistance following prolonged therapy for invasive candidiasis secondary to Candida glabrata infection.

Authors:  George R Thompson; Nathan P Wiederhold; Ana C Vallor; Nyria C Villareal; James S Lewis; Thomas F Patterson
Journal:  Antimicrob Agents Chemother       Date:  2008-08-01       Impact factor: 5.191

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8.  Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpoint.

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Journal:  Antimicrob Agents Chemother       Date:  2009-06-22       Impact factor: 5.191

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  16 in total

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2.  Comparison of dimethyl sulfoxide and water as solvents for echinocandin susceptibility testing by the EUCAST methodology.

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6.  Rapid development of Candida krusei echinocandin resistance during caspofungin therapy.

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9.  Role of FKS Mutations in Candida glabrata: MIC values, echinocandin resistance, and multidrug resistance.

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10.  Evaluation of caspofungin susceptibility testing by the new Vitek 2 AST-YS06 yeast card using a unique collection of FKS wild-type and hot spot mutant isolates, including the five most common candida species.

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