Literature DB >> 22383326

The art of filling protein pockets efficiently with octahedral metal complexes.

Sebastian Blanck1, Jasna Maksimoska, Julia Baumeister, Klaus Harms, Ronen Marmorstein, Eric Meggers.   

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Year:  2012        PMID： 22383326      PMCID： PMC3509364          DOI： 10.1002/anie.201108865

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  12 in total

1.  Iridium complex with antiangiogenic properties.

Authors:  Alexander Wilbuer; Danielle H Vlecken; Daan J Schmitz; Katja Kräling; Klaus Harms; Christoph P Bagowski; Eric Meggers
Journal:  Angew Chem Int Ed Engl       Date:  2010-05-17       Impact factor: 15.336

2.  Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.

Authors:  Paul A Clemons; Nicole E Bodycombe; Hyman A Carrinski; J Anthony Wilson; Alykhan F Shamji; Bridget K Wagner; Angela N Koehler; Stuart L Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-18       Impact factor: 11.205

3.  The active conformation of the PAK1 kinase domain.

Authors:  Ming Lei; Michael A Robinson; Stephen C Harrison
Journal:  Structure       Date:  2005-05       Impact factor: 5.006

4.  Rapid access to unexplored chemical space by ligand scanning around a ruthenium center: discovery of potent and selective protein kinase inhibitors.

Authors:  Howard Bregman; Patrick J Carroll; Eric Meggers
Journal:  J Am Chem Soc       Date:  2006-01-25       Impact factor: 15.419

5.  Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones.

Authors:  John Spencer; Andrew P Mendham; Arun K Kotha; Simon C W Richardson; Elizabeth A Hillard; Gérard Jaouen; Louise Male; Michael B Hursthouse
Journal:  Dalton Trans       Date:  2008-11-18       Impact factor: 4.390

6.  Organometallic Pyridylnaphthalimide Complexes as Protein Kinase Inhibitors.

Authors:  Sebastian Blanck; Thomas Cruchter; Adina Vultur; Radostan Riedel; Klaus Harms; Meenhard Herlyn; Eric Meggers
Journal:  Organometallics       Date:  2011-07-18       Impact factor: 3.876

7.  Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors.

Authors:  Li Feng; Yann Geisselbrecht; Sebastian Blanck; Alexander Wilbuer; G Ekin Atilla-Gokcumen; Panagis Filippakopoulos; Katja Kräling; Mehmet Ali Celik; Klaus Harms; Jasna Maksimoska; Ronen Marmorstein; Gernot Frenking; Stefan Knapp; Lars-Oliver Essen; Eric Meggers
Journal:  J Am Chem Soc       Date:  2011-03-29       Impact factor: 15.419

8.  (Arene)Ru(II) complexes of epidermal growth factor receptor inhibiting tyrphostins with enhanced selectivity and cytotoxicity in cancer cells.

Authors:  B Biersack; M Zoldakova; K Effenberger; R Schobert
Journal:  Eur J Med Chem       Date:  2010-01-28       Impact factor: 6.514

9.  Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.

Authors:  M Lei; W Lu; W Meng; M C Parrini; M J Eck; B J Mayer; S C Harrison
Journal:  Cell       Date:  2000-08-04       Impact factor: 41.582

10.  Targeting large kinase active site with rigid, bulky octahedral ruthenium complexes.

Authors:  Jasna Maksimoska; Li Feng; Klaus Harms; Chunling Yi; Joseph Kissil; Ronen Marmorstein; Eric Meggers
Journal:  J Am Chem Soc       Date:  2008-11-26       Impact factor: 15.419
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  16 in total

1.  Novel enantiopure cyclopentadienyl Ti(IV) oximato compounds as potential anticancer agents.

Authors:  Isabel de la Cueva-Alique; Laura Muñoz-Moreno; Yosra Benabdelouahab; Benelita T Elie; Mohammed Amin El Amrani; Marta E G Mosquera; María Contel; Ana M Bajo; Tomás Cuenca; Eva Royo
Journal:  J Inorg Biochem       Date:  2015-12-09       Impact factor: 4.155

2.  Bioactive cyclometalated phthalimides: design, synthesis and kinase inhibition.

Authors:  Sebastian Blanck; Yann Geisselbrecht; Katja Kräling; Stephen Middel; Thomas Mietke; Klaus Harms; Lars-Oliver Essen; Eric Meggers
Journal:  Dalton Trans       Date:  2012-06-26       Impact factor: 4.390

3.  An organometallic inhibitor for the human repair enzyme 7,8-dihydro-8-oxoguanosine triphosphatase.

Authors:  Manuel Streib; Katja Kräling; Kristin Richter; Xiulan Xie; Holger Steuber; Eric Meggers
Journal:  Angew Chem Int Ed Engl       Date:  2013-11-20       Impact factor: 15.336

4.  Hydrogen bonding and anticancer properties of water-soluble chiral p-cymene Ru(II) compounds with amino-oxime ligands.

Authors:  Yosra Benabdelouahab; Laura Muñoz-Moreno; Malgorzata Frik; Isabel de la Cueva-Alique; Mohammed Amin El Amrani; María Contel; Ana M Bajo; Tomás Cuenca; Eva Royo
Journal:  Eur J Inorg Chem       Date:  2015-04-09       Impact factor: 2.524

Review 5.  The development of anticancer ruthenium(ii) complexes: from single molecule compounds to nanomaterials.

Authors:  Leli Zeng; Pranav Gupta; Yanglu Chen; Enju Wang; Liangnian Ji; Hui Chao; Zhe-Sheng Chen
Journal:  Chem Soc Rev       Date:  2017-10-02       Impact factor: 54.564

6.  FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas.

Authors:  Silvia Licciulli; Jasna Maksimoska; Chun Zhou; Scott Troutman; Smitha Kota; Qin Liu; Sergio Duron; David Campbell; Jonathan Chernoff; Jeffrey Field; Ronen Marmorstein; Joseph L Kissil
Journal:  J Biol Chem       Date:  2013-08-19       Impact factor: 5.157

7.  Rhenium Complexes with Red-Light-Induced Anticancer Activity.

Authors:  Kathrin Wähler; Anja Ludewig; Patrick Szabo; Klaus Harms; Eric Meggers
Journal:  Eur J Inorg Chem       Date:  2014-02-01       Impact factor: 2.524

8.  Rhenium complexes with visible-light-induced anticancer activity.

Authors:  Anja Kastl; Sandra Dieckmann; Kathrin Wähler; Timo Völker; Lena Kastl; Anna Lena Merkel; Adina Vultur; Batool Shannan; Klaus Harms; Matthias Ocker; Wolfgang J Parak; Meenhard Herlyn; Eric Meggers
Journal:  ChemMedChem       Date:  2013-04-08       Impact factor: 3.466

9.  Mirror-image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity.

Authors:  Ying Fu; Rina Soni; María J Romero; Ana M Pizarro; Luca Salassa; Guy J Clarkson; Jessica M Hearn; Abraha Habtemariam; Martin Wills; Peter J Sadler
Journal:  Chemistry       Date:  2013-09-23       Impact factor: 5.236

10.  Non-ATP-Mimetic Organometallic Protein Kinase Inhibitor.

Authors:  Kathrin Wähler; Katja Kräling; Holger Steuber; Eric Meggers
Journal:  ChemistryOpen       Date:  2013-09-05       Impact factor: 2.911
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