| Literature DB >> 27175101 |
Yosra Benabdelouahab1, Laura Muñoz-Moreno2, Malgorzata Frik3, Isabel de la Cueva-Alique1, Mohammed Amin El Amrani4, María Contel3, Ana M Bajo2, Tomás Cuenca1, Eva Royo1.
Abstract
The investigation of the hydrogen-bonding effect on the aggregation tendency of ruthenium compounds [(η6-p-cymene)Ru(κNHR,κNOH)Cl]Cl (R = Ph (1a), Bn (1b)) and [(η6-p-cymene)Ru(κ2NH(2-pic),κNOH)][PF6]2 (1c), [(η6-p-cymene)Ru(κNHBn,κNO)Cl] (2b) and [(η6-p-cymene)Ru(κNBn,κ2NO)] (3b), has been performed by means of concentration dependence 1H NMR chemical shifts and DOSY experiments. The synthesis and full characterization of new compounds 1c, [(η6-p-cymene)Ru(κNPh,κ2NO)] (3a) and 3b are also reported. The effect of the water soluble ruthenium complexes 1a-1c on cytotoxicity, cell adhesion and cell migration of the androgen-independent prostate cancer PC3 cells have been assessed by MTT, adhesion to type-I-collagen and recovery of monolayer wounds assays, respectively. Interactions of 1a-1c with DNA and human serum albumin have also been studied. Altogether, the properties reported herein suggest that ruthenium compounds 1a-1c have considerable potential as anticancer agents against advanced prostate cancer.Entities:
Keywords: anticancer; arene ruthenium compounds; chiral syntheses; non-covalent interactions; oxime
Year: 2015 PMID： 27175101 PMCID： PMC4862618 DOI： 10.1002/ejic.201500097
Source DB: PubMed Journal: Eur J Inorg Chem ISSN： 1434-1948 Impact factor: 2.524