PURPOSE: Predicting prognosis in advanced cancer aids physicians in clinical decision making and can help patients and their families to prepare for the time ahead. MATERIALS AND METHODS: This multicenter, observational, prospective, nonrandomized population-based study evaluated life span prediction of four prognostic scores used in palliative care: the original palliative prognostic score (PaP Score), a variant of PaP Score including delirium (D-PaP Score), the Palliative Performance Scale, and the Palliative Prognostic Index. RESULTS: A total of 549 patients were enrolled onto the study. Median survival of the entire group was 22 days (95% confidence intervals [95% CI] = 19-24). All four prognostic models discriminated well between groups of patients with different survival probabilities. Log-rank tests were all highly significant (p < .0001). The PaP and D-PaP scores were the most accurate, with a C index of 0.72 (95% CI = 0.70-0.73) and 0.73 (95% CI = 0.71-0.74), respectively. CONCLUSION: It can be confirmed that all four prognostic scores used in palliative care studies accurately identify classes of patients with different survival probabilities. The PaP Score has been extensively validated and shows high accuracy and reproducibility in different settings.
PURPOSE: Predicting prognosis in advanced cancer aids physicians in clinical decision making and can help patients and their families to prepare for the time ahead. MATERIALS AND METHODS: This multicenter, observational, prospective, nonrandomized population-based study evaluated life span prediction of four prognostic scores used in palliative care: the original palliative prognostic score (PaP Score), a variant of PaP Score including delirium (D-PaP Score), the Palliative Performance Scale, and the Palliative Prognostic Index. RESULTS: A total of 549 patients were enrolled onto the study. Median survival of the entire group was 22 days (95% confidence intervals [95% CI] = 19-24). All four prognostic models discriminated well between groups of patients with different survival probabilities. Log-rank tests were all highly significant (p < .0001). The PaP and D-PaP scores were the most accurate, with a C index of 0.72 (95% CI = 0.70-0.73) and 0.73 (95% CI = 0.71-0.74), respectively. CONCLUSION: It can be confirmed that all four prognostic scores used in palliative care studies accurately identify classes of patients with different survival probabilities. The PaP Score has been extensively validated and shows high accuracy and reproducibility in different settings.
Authors: A Caraceni; O Nanni; M Maltoni; L Piva; M Indelli; E Arnoldi; M Monti; L Montanari; D Amadori; F De Conno Journal: Cancer Date: 2000-09-01 Impact factor: 6.860
Authors: Marco Maltoni; Augusto Caraceni; Cinzia Brunelli; Bert Broeckaert; Nicholas Christakis; Steffen Eychmueller; Paul Glare; Maria Nabal; Antonio Viganò; Philip Larkin; Franco De Conno; Geoffrey Hanks; Stein Kaasa Journal: J Clin Oncol Date: 2005-09-01 Impact factor: 44.544
Authors: Emanuela Scarpi; Monia Dall'Agata; Vittorina Zagonel; Teresa Gamucci; Raffaella Bertè; Elisabetta Sansoni; Elena Amaducci; Chiara Maria Broglia; Sara Alquati; Ferdinando Garetto; Stefania Schiavon; Silvia Quadrini; Elena Orlandi; Andrea Casadei Gardini; Silvia Ruscelli; Daris Ferrari; Maria Simona Pino; Roberto Bortolussi; Federica Negri; Silvia Stragliotto; Filomena Narducci; Martina Valgiusti; Alberto Farolfi; Oriana Nanni; Romina Rossi; Marco Maltoni Journal: Support Care Cancer Date: 2018-10-24 Impact factor: 3.603