| Literature DB >> 22362099 |
Takuya Sakurai1, Junetsu Ogasawara, Takako Kizaki, Yoshinaga Ishibashi, Yoshikazu Sumitani, Kazuto Takahashi, Hitoshi Ishida, Hiromi Miyazaki, Daizoh Saitoh, Shukoh Haga, Tetsuya Izawa, Hideki Ohno.
Abstract
Recent increases in the number of obese individuals and individuals suffering from lifestyle-related diseases, such as type 2 diabetes, that accompany obesity have become a serious social problem. White adipose tissue (WAT) is more than a mere organ for storage of energy; it is also a highly active metabolic and endocrine organ that secretes physiologically active substances collectively known as adipokines, including tumor necrosis factor-α and adiponectin. Dysregulated expression of adipokines in WAT that is hypertrophied by obesity has been closely associated with the phenomenon of insulin resistance. Therefore, WAT is currently considered to be one of the tissues that promote lifestyle-related diseases. Reduction of excess WAT that results from obesity is seen as an important strategy in preventing and improving lifestyle-related diseases. This review shows that exercise training as well as intake of supplements, such as polyphenols, is one strategy for this, because this regimen can result in reduction of WAT mass, which affects the expression and secretory response of adipokines.Entities:
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Year: 2012 PMID： 22362099 PMCID： PMC3437364 DOI： 10.1007/s12199-012-0271-0
Source DB: PubMed Journal: Environ Health Prev Med ISSN： 1342-078X Impact factor: 3.674