| Literature DB >> 22361291 |
José Almeida Cruz1, Marc-Frédérick Blanchet, Michal Boniecki, Janusz M Bujnicki, Shi-Jie Chen, Song Cao, Rhiju Das, Feng Ding, Nikolay V Dokholyan, Samuel Coulbourn Flores, Lili Huang, Christopher A Lavender, Véronique Lisi, François Major, Katarzyna Mikolajczak, Dinshaw J Patel, Anna Philips, Tomasz Puton, John Santalucia, Fredrick Sijenyi, Thomas Hermann, Kristian Rother, Magdalena Rother, Alexander Serganov, Marcin Skorupski, Tomasz Soltysinski, Parin Sripakdeevong, Irina Tuszynska, Kevin M Weeks, Christina Waldsich, Michael Wildauer, Neocles B Leontis, Eric Westhof.
Abstract
We report the results of a first, collective, blind experiment in RNA three-dimensional (3D) structure prediction, encompassing three prediction puzzles. The goals are to assess the leading edge of RNA structure prediction techniques; compare existing methods and tools; and evaluate their relative strengths, weaknesses, and limitations in terms of sequence length and structural complexity. The results should give potential users insight into the suitability of available methods for different applications and facilitate efforts in the RNA structure prediction community in ongoing efforts to improve prediction tools. We also report the creation of an automated evaluation pipeline to facilitate the analysis of future RNA structure prediction exercises.Mesh：
Substances：
Year: 2012 PMID： 22361291 PMCID： PMC3312550 DOI： 10.1261/rna.031054.111
Source DB: PubMed Journal: RNA ISSN： 1355-8382 Impact factor: 4.942