| Literature DB >> 22359426 |
Mario J Simirgiotis1, Seiji Adachi, Satoshi To, Hui Yang, Kurt A Reynertson, Margaret J Basile, Roberto R Gil, I Bernard Weinstein, Edward J Kennelly.
Abstract
Bioassay-guided fractionation of the methanolic extracts of the pulp and seeds of the fruits of Syzygium samarangense Merr. & Perry (Blume) led to the identification of four cytotoxic compounds and eight antioxidants on the basis of HPLC-PDA analysis, MS, and various NMR spectroscopic techniques. Three C-methylated chalcones, 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone (1), 2',4'-dihydroxy-3'-methyl-6'-methoxychalcone (stercurensin, 2), and 2',4'-dihydroxy-6'-methoxychalcone (cardamonin, 3), were isolated and displayed cytotoxic activity (IC(50) = 10, 35, and 35 μM, respectively) against the SW-480 human colon cancer cell line. Also a number of known antioxidants were obtained including six quercetin glycosides: reynoutrin (4), hyperin (5), myricitrin (6), quercitrin (7), quercetin (9), and guaijaverin (10), one flavanone: (S)-pinocembrin (8), and two phenolic acids: gallic acid (11) and ellagic acid (12).Entities:
Year: 2008 PMID： 22359426 PMCID： PMC3282680 DOI： 10.1016/j.foodchem.2007.08.086
Source DB: PubMed Journal: Food Chem ISSN： 0308-8146 Impact factor: 7.514