Literature DB >> 16621533

Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.

Tan Siew Kiat1, Richard Pippen, Rohana Yusof, Halijah Ibrahim, Norzulaani Khalid, Noorsaadah Abd Rahman.   

Abstract

Boesenbergia rotunda (L.) cyclohexenyl chalcone derivatives, 4-hydroxypanduratin A and panduratin A, showed good competitive inhibitory activities towards dengue 2 virus NS3 protease with the Ki values of 21 and 25 microM, respectively, whilst those of pinostrobin and cardamonin were observed to be non-competitive. NMR and GCMS spectroscopic data formed the basis of assignment of structures of the six compounds isolated.

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Year:  2006        PMID： 16621533     DOI： 10.1016/j.bmcl.2005.12.075

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  63 in total

1.  Silver nanoparticle-catalyzed Diels-Alder cycloadditions of 2'-hydroxychalcones.

Authors:  Huan Cong; Clinton F Becker; Sean J Elliott; Mark W Grinstaff; John A Porco
Journal:  J Am Chem Soc       Date:  2010-06-02       Impact factor: 15.419

2.  Structural and functional parameters of the flaviviral protease: a promising antiviral drug target.

Authors:  Sergey A Shiryaev; Alex Y Strongin
Journal:  Future Virol       Date:  2010-09-01       Impact factor: 1.831

3.  Anthracene-based inhibitors of dengue virus NS2B-NS3 protease.

Authors:  Suzanne M Tomlinson; Stanley J Watowich
Journal:  Antiviral Res       Date:  2010-12-23       Impact factor: 5.970

4.  An overview on cardamonin.

Authors:  Luís Moreira Gonçalves; Inês Maria Valente; José António Rodrigues
Journal:  J Med Food       Date:  2014-01-16       Impact factor: 2.786

5.  The Utility of the HSAB Principle via the Fukui Function in Biological Systems.

Authors:  John Faver; Kenneth M Merz
Journal:  J Chem Theory Comput       Date:  2010-02-09       Impact factor: 6.006

6.  Cytotoxic chalcones and antioxidants from the fruits of a Syzygium samarangense (Wax Jambu).

Authors:  Mario J Simirgiotis; Seiji Adachi; Satoshi To; Hui Yang; Kurt A Reynertson; Margaret J Basile; Roberto R Gil; I Bernard Weinstein; Edward J Kennelly
Journal:  Food Chem       Date:  2008-03-15       Impact factor: 7.514

7.  Antiviral actions of flavanoid-derived compounds on dengue virus type-2.

Authors:  Mudiana Muhamad; Lee Yean Kee; Noorsaadah Abd Rahman; Rohana Yusof
Journal:  Int J Biol Sci       Date:  2010-05-23       Impact factor: 6.580

8.  A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease.

Authors:  Chi-Chen Yang; Han-Shu Hu; Ren-Huang Wu; Szu-Huei Wu; Shiow-Ju Lee; Weir-Torn Jiaang; Jyh-Haur Chern; Zhi-Shun Huang; Huey-Nan Wu; Chung-Ming Chang; Andrew Yueh
Journal:  Antimicrob Agents Chemother       Date:  2013-10-21       Impact factor: 5.191

Review 9.  The flavivirus protease as a target for drug discovery.

Authors:  Matthew Brecher; Jing Zhang; Hongmin Li
Journal:  Virol Sin       Date:  2013-11-14       Impact factor: 4.327

10.  In Vitro Antiviral Activity of α-Mangostin against Dengue Virus Serotype-2 (DENV-2).

Authors:  Kingshuk Panda; Kalichamy Alagarasu; Poonam Patil; Megha Agrawal; Ashwini More; Naveen V Kumar; Prathama S Mainkar; Deepti Parashar; Sarah Cherian
Journal:  Molecules       Date:  2021-05-19       Impact factor: 4.411
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