| Literature DB >> 22355129 |
Hanbing Lu1, Qihong Zou, Hong Gu, Marcus E Raichle, Elliot A Stein, Yihong Yang.
Abstract
The default mode network (DMN) in humans has been suggested to support a variety of cognitive functions and has been implicated in an array of neuropsychological disorders. However, its function(s) remains poorly understood. We show that rats possess a DMN that is broadly similar to the DMNs of nonhuman primates and humans. Our data suggest that, despite the distinct evolutionary paths between rodent and primate brain, a well-organized, intrinsically coherent DMN appears to be a fundamental feature in the mammalian brain whose primary functions might be to integrate multimodal sensory and affective information to guide behavior in anticipation of changing environmental contingencies.Entities:
Mesh:
Year: 2012 PMID: 22355129 PMCID: PMC3309754 DOI: 10.1073/pnas.1200506109
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN: 0027-8424 Impact factor: 11.205