| Literature DB >> 27393420 |
Zhiwei Ma1, Pablo Perez1, Zilu Ma1, Yikang Liu1, Christina Hamilton2, Zhifeng Liang1, Nanyin Zhang3.
Abstract
Connectivity-based parcellation approaches present an innovative method to segregate the brain into functionally specialized regions. These approaches have significantly advanced our understanding of the human brain organization. However, parallel progress in animal research is sparse. Using resting-state fMRI data and a novel, data-driven parcellation method, we have obtained robust functional parcellations of the rat brain. These functional parcellations reveal the regional specialization of the rat brain, which exhibited high within-parcel homogeneity and high reproducibility across animals. Graph analysis of the whole-brain network constructed based on these functional parcels indicates that the rat brain has a topological organization similar to humans, characterized by both segregation and integration. Our study also provides compelling evidence that the cingulate cortex is a functional hub region conserved from rodents to humans. Together, this study has characterized the rat brain specialization and integration, and has significantly advanced our understanding of the rat brain organization. In addition, it is valuable for studies of comparative functional neuroanatomy in mammalian brains.Entities:
Keywords: Integration; Rat; Resting-state functional connectivity; Specialization; Whole-brain parcellation
Mesh：
Year: 2016 PMID： 27393420 PMCID： PMC5217744 DOI： 10.1016/j.neuroimage.2016.07.007
Source DB: PubMed Journal: Neuroimage ISSN： 1053-8119 Impact factor: 6.556