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Literature DB >> 22352377

PASADENA hyperpolarized 13C phospholactate.

Roman V Shchepin¹, Aaron M Coffey, Kevin W Waddell, Eduard Y Chekmenev.

Abstract

We demonstrate that potassium 1-(13)C-phosphoenolpyruvate becomes hyperpolarized potassium 1-(13)C-phospholactate with (13)C T(1) = 36 s after molecular hydrogenation by PASADENA (Parahydrogen and Synthesis Allows Dramatically Enhanced Nuclear Alignment). This proof-of-principle study was conducted with a fully protonated molecular precursor. (13)C was polarized to a level of 1%, corresponding to nearly 4000-fold sensitivity enhancement at 3 T. The relevant homo- and heteronuclear spin-spin couplings are reported.

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Year: 2012 PMID： 22352377 PMCID： PMC3318994 DOI： 10.1021/ja210639c

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

17 in total

1. Parahydrogen-induced polarization in imaging: subsecond (13)C angiography.

Authors: K Golman; O Axelsson; H Jóhannesson; S Månsson; C Olofsson; J S Petersson
Journal: Magn Reson Med Date: 2001-07 Impact factor: 4.668

2. Transformation of symmetrization order to nuclear-spin magnetization by chemical reaction and nuclear magnetic resonance.

Authors:
Journal: Phys Rev Lett Date: 1986-11-24 Impact factor: 9.161

3. Ultra-fast three dimensional imaging of hyperpolarized 13C in vivo.

Authors: P Bhattacharya; K Harris; A P Lin; M Mansson; V A Norton; W H Perman; D P Weitekamp; B D Ross
Journal: MAGMA Date: 2005-11-23 Impact factor: 2.310

4. Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.

Authors: John Kurhanewicz; Daniel B Vigneron; Kevin Brindle; Eduard Y Chekmenev; Arnaud Comment; Charles H Cunningham; Ralph J Deberardinis; Gary G Green; Martin O Leach; Sunder S Rajan; Rahim R Rizi; Brian D Ross; Warren S Warren; Craig R Malloy
Journal: Neoplasia Date: 2011-02 Impact factor: 5.715

5. A large volume double channel 1H-X RF probe for hyperpolarized magnetic resonance at 0.0475 T.

Authors: Aaron M Coffey; Roman V Shchepin; Ken Wilkens; Kevin W Waddell; Eduard Y Chekmenev
Journal: J Magn Reson Date: 2012-04-30 Impact factor: 2.229

6. In situ detection of PHIP at 48 mT: demonstration using a centrally controlled polarizer.

Authors: Kevin W Waddell; Aaron M Coffey; Eduard Y Chekmenev
Journal: J Am Chem Soc Date: 2010-12-09 Impact factor: 15.419

7. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

Authors: Sam E Day; Mikko I Kettunen; Ferdia A Gallagher; De-En Hu; Mathilde Lerche; Jan Wolber; Klaes Golman; Jan Henrik Ardenkjaer-Larsen; Kevin M Brindle
Journal: Nat Med Date: 2007-10-28 Impact factor: 53.440

8. Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate.

Authors: Ferdia A Gallagher; Mikko I Kettunen; Sam E Day; De-En Hu; Jan Henrik Ardenkjaer-Larsen; René in 't Zandt; Pernille R Jensen; Magnus Karlsson; Klaes Golman; Mathilde H Lerche; Kevin M Brindle
Journal: Nature Date: 2008-05-28 Impact factor: 49.962

9. Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.

Authors: Mark J Albers; Robert Bok; Albert P Chen; Charles H Cunningham; Matt L Zierhut; Vickie Yi Zhang; Susan J Kohler; James Tropp; Ralph E Hurd; Yi-Fen Yen; Sarah J Nelson; Daniel B Vigneron; John Kurhanewicz
Journal: Cancer Res Date: 2008-10-15 Impact factor: 12.701

10. Hyperpolarized (1)H NMR employing low gamma nucleus for spin polarization storage.

Authors: Eduard Y Chekmenev; Valerie A Norton; Daniel P Weitekamp; Pratip Bhattacharya
Journal: J Am Chem Soc Date: 2009-03-11 Impact factor: 15.419

39 in total

Review 1. NMR-based Stable Isotope Resolved Metabolomics in systems biochemistry.

Authors: Andrew N Lane; Teresa W-M Fan
Journal: Arch Biochem Biophys Date: 2017-03-02 Impact factor: 4.013

2. Toward Production of Pure ¹³C Hyperpolarized Metabolites Using Heterogeneous Parahydrogen-Induced Polarization of Ethyl[1-¹³C]acetate.

Authors: K V Kovtunov; D A Barskiy; O G Salnikov; R V Shchepin; A M Coffey; L M Kovtunova; V I Bukhtiyarov; I V Koptyug; E Y Chekmenev
Journal: RSC Adv Date: 2016-07-15 Impact factor: 3.361

PASADENA hyperpolarized 13C phospholactate.

1. Parahydrogen-induced polarization in imaging: subsecond (13)C angiography.

2. Transformation of symmetrization order to nuclear-spin magnetization by chemical reaction and nuclear magnetic resonance.

3. Ultra-fast three dimensional imaging of hyperpolarized 13C in vivo.

4. Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research.

5. A large volume double channel 1H-X RF probe for hyperpolarized magnetic resonance at 0.0475 T.

6. In situ detection of PHIP at 48 mT: demonstration using a centrally controlled polarizer.

7. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

8. Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate.

9. Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading.

10. Hyperpolarized (1)H NMR employing low gamma nucleus for spin polarization storage.

Review 1. NMR-based Stable Isotope Resolved Metabolomics in systems biochemistry.

2. Toward Production of Pure ¹³C Hyperpolarized Metabolites Using Heterogeneous Parahydrogen-Induced Polarization of Ethyl[1-¹³C]acetate.

Review 3. Hyperpolarized NMR Spectroscopy: d-DNP, PHIP, and SABRE Techniques.

4. Heteronuclear refocusing by nonlinear phase and amplitude modulation on a single transmitter channel.

5. Nuclear spin hyperpolarization of the solvent using signal amplification by reversible exchange (SABRE).

Review 6. Can NMR solve some significant challenges in metabolomics?

7. Parahydrogen Induced Polarization with Rh-based Monodentate Ligand in Water.

8. Dephosphorylation and biodistribution of 1-¹³C-phospholactate in vivo.

9. Efficient Batch-Mode Parahydrogen-Induced Polarization of Propane.

Review 10. Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization.