Literature DB >> 28042472

Toward Production of Pure 13C Hyperpolarized Metabolites Using Heterogeneous Parahydrogen-Induced Polarization of Ethyl[1-13C]acetate.

K V Kovtunov1, D A Barskiy2, O G Salnikov1, R V Shchepin2, A M Coffey2, L M Kovtunova3, V I Bukhtiyarov3, I V Koptyug1, E Y Chekmenev4.   

Abstract

Here, we report the production of 13C-hyperpolarized ethyl acetate via heterogeneously catalyzed pairwise addition of parahydrogen to vinyl acetate over TiO2-supported rhodium nanoparticles, followed by magnetic field cycling. Importantly, the hyperpolarization is demonstrated even at the natural abundance of 13C isotope (ca. 1.1%) along with the easiest separation of the catalyst from the hyperpolarized liquid.

Entities:  

Year:  2016        PMID： 28042472      PMCID： PMC5193475          DOI： 10.1039/C6RA15808K

Source DB:  PubMed          Journal:  RSC Adv        ISSN： 2046-2069            Impact factor:   3.361


  36 in total

1.  Parahydrogen-induced polarization in imaging: subsecond (13)C angiography.

Authors:  K Golman; O Axelsson; H Jóhannesson; S Månsson; C Olofsson; J S Petersson
Journal:  Magn Reson Med       Date:  2001-07       Impact factor: 4.668

2.  Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1-(13)C diethyl succinate.

Authors:  Niki M Zacharias; Henry R Chan; Napapon Sailasuta; Brian D Ross; Pratip Bhattacharya
Journal:  J Am Chem Soc       Date:  2011-12-22       Impact factor: 15.419

3.  Transformation of symmetrization order to nuclear-spin magnetization by chemical reaction and nuclear magnetic resonance.

Authors: 
Journal:  Phys Rev Lett       Date:  1986-11-24       Impact factor: 9.161

Review 4.  Dynamic nuclear polarization at high magnetic fields.

Authors:  Thorsten Maly; Galia T Debelouchina; Vikram S Bajaj; Kan-Nian Hu; Chan-Gyu Joo; Melody L Mak-Jurkauskas; Jagadishwar R Sirigiri; Patrick C A van der Wel; Judith Herzfeld; Richard J Temkin; Robert G Griffin
Journal:  J Chem Phys       Date:  2008-02-07       Impact factor: 3.488

5.  Use of labile precursors for the generation of hyperpolarized molecules from hydrogenation with parahydrogen and aqueous-phase extraction.

Authors:  Francesca Reineri; Alessandra Viale; Silvano Ellena; Tommaso Boi; Valeria Daniele; Roberto Gobetto; Silvio Aime
Journal:  Angew Chem Int Ed Engl       Date:  2011-06-22       Impact factor: 15.336

6.  NMR signal enhancement for hyperpolarized fluids continuously generated in hydrogenation reactions with parahydrogen.

Authors:  Danila A Barskiy; Oleg G Salnikov; Kirill V Kovtunov; Igor V Koptyug
Journal:  J Phys Chem A       Date:  2015-02-02       Impact factor: 2.781

Review 7.  The theory and practice of hyperpolarization in magnetic resonance using parahydrogen.

Authors:  Richard A Green; Ralph W Adams; Simon B Duckett; Ryan E Mewis; David C Williamson; Gary G R Green
Journal:  Prog Nucl Magn Reson Spectrosc       Date:  2012-03-15       Impact factor: 9.795

8.  Comparison of kinetic models for analysis of pyruvate-to-lactate exchange by hyperpolarized 13 C NMR.

Authors:  Crystal Harrison; Chendong Yang; Ashish Jindal; Ralph J DeBerardinis; M A Hooshyar; Matthew Merritt; A Dean Sherry; Craig R Malloy
Journal:  NMR Biomed       Date:  2012-03-26       Impact factor: 4.044

9.  Parahydrogen-induced polarization (PHIP) hyperpolarized MR receptor imaging in vivo: a pilot study of 13C imaging of atheroma in mice.

Authors:  Pratip Bhattacharya; Eduard Y Chekmenev; Wanda F Reynolds; Shawn Wagner; Niki Zacharias; Henry R Chan; Rolf Bünger; Brian D Ross
Journal:  NMR Biomed       Date:  2011-04-28       Impact factor: 4.044

10.  Efficient Synthesis of Molecular Precursors for Para-Hydrogen-Induced Polarization of Ethyl Acetate-1-(13) C and Beyond.

Authors:  Roman V Shchepin; Danila A Barskiy; Aaron M Coffey; Isaac V Manzanera Esteve; Eduard Y Chekmenev
Journal:  Angew Chem Int Ed Engl       Date:  2016-04-08       Impact factor: 15.336
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  14 in total

1.  Parahydrogen-Induced Polarization of 1-13C-Acetates and 1-13C-Pyruvates Using Sidearm Hydrogenation of Vinyl, Allyl, and Propargyl Esters.

Authors:  Oleg G Salnikov; Nikita V Chukanov; Roman V Shchepin; Isaac V Manzanera Esteve; Kirill V Kovtunov; Igor V Koptyug; Eduard Y Chekmenev
Journal:  J Phys Chem C Nanomater Interfaces       Date:  2019-04-19       Impact factor: 4.126

2.  A versatile synthetic route to the preparation of 15 N heterocycles.

Authors:  Nikita V Chukanov; Bryce E Kidd; Larisa M Kovtunova; Valerii I Bukhtiyarov; Roman V Shchepin; Eduard Y Chekmenev; Boyd M Goodson; Kirill V Kovtunov; Igor V Koptyug
Journal:  J Labelled Comp Radiopharm       Date:  2019-01-07       Impact factor: 1.921

3.  Pulse-Programmable Magnetic Field Sweeping of Parahydrogen-Induced Polarization by Side Arm Hydrogenation.

Authors:  Baptiste Joalland; Andreas B Schmidt; Mohammad S H Kabir; Nikita V Chukanov; Kirill V Kovtunov; Igor V Koptyug; Jürgen Hennig; Jan-Bernd Hövener; Eduard Y Chekmenev
Journal:  Anal Chem       Date:  2019-12-23       Impact factor: 6.986

4.  Heterogeneous Microtesla SABRE Enhancement of 15 N NMR Signals.

Authors:  Kirill V Kovtunov; Larisa M Kovtunova; Max E Gemeinhardt; Andrey V Bukhtiyarov; Jonathan Gesiorski; Valerii I Bukhtiyarov; Eduard Y Chekmenev; Igor V Koptyug; Boyd M Goodson
Journal:  Angew Chem Int Ed Engl       Date:  2017-07-28       Impact factor: 15.336

5.  Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques.

Authors:  Andreas B Schmidt; C Russell Bowers; Kai Buckenmaier; Eduard Y Chekmenev; Henri de Maissin; James Eills; Frowin Ellermann; Stefan Glöggler; Jeremy W Gordon; Stephan Knecht; Igor V Koptyug; Jule Kuhn; Andrey N Pravdivtsev; Francesca Reineri; Thomas Theis; Kolja Them; Jan-Bernd Hövener
Journal:  Anal Chem       Date:  2022-01-01       Impact factor: 6.986

6.  Production of Pure Aqueous 13 C-Hyperpolarized Acetate by Heterogeneous Parahydrogen-Induced Polarization.

Authors:  Kirill V Kovtunov; Danila A Barskiy; Roman V Shchepin; Oleg G Salnikov; Igor P Prosvirin; Andrey V Bukhtiyarov; Larisa M Kovtunova; Valerii I Bukhtiyarov; Igor V Koptyug; Eduard Y Chekmenev
Journal:  Chemistry       Date:  2016-10-10       Impact factor: 5.236

Review 7.  Parahydrogen-Based Hyperpolarization for Biomedicine.

Authors:  Jan-Bernd Hövener; Andrey N Pravdivtsev; Bryce Kidd; C Russell Bowers; Stefan Glöggler; Kirill V Kovtunov; Markus Plaumann; Rachel Katz-Brull; Kai Buckenmaier; Alexej Jerschow; Francesca Reineri; Thomas Theis; Roman V Shchepin; Shawn Wagner; Pratip Bhattacharya; Niki M Zacharias; Eduard Y Chekmenev
Journal:  Angew Chem Int Ed Engl       Date:  2018-08-01       Impact factor: 15.336

8.  A pulse programmable parahydrogen polarizer using a tunable electromagnet and dual channel NMR spectrometer.

Authors:  Aaron M Coffey; Roman V Shchepin; Bibo Feng; Raul D Colon; Ken Wilkens; Kevin W Waddell; Eduard Y Chekmenev
Journal:  J Magn Reson       Date:  2017-09-30       Impact factor: 2.229

9.  Heterogeneous 1 H and 13 C Parahydrogen-Induced Polarization of Acetate and Pyruvate Esters.

Authors:  Oleg G Salnikov; Nikita V Chukanov; Larisa M Kovtunova; Valerii I Bukhtiyarov; Kirill V Kovtunov; Roman V Shchepin; Igor V Koptyug; Eduard Y Chekmenev
Journal:  Chemphyschem       Date:  2021-05-28       Impact factor: 3.520

10.  Aqueous, Heterogeneous Parahydrogen-Induced 15N Polarization.

Authors:  Liana B Bales; Kirill V Kovtunov; Danila A Barskiy; Roman V Shchepin; Aaron M Coffey; Larisa M Kovtunova; Andrey V Bukhtiyarov; Matthew A Feldman; Valerii I Bukhtiyarov; Eduard Y Chekmenev; Igor V Koptyug; Boyd M Goodson
Journal:  J Phys Chem C Nanomater Interfaces       Date:  2017-06-21       Impact factor: 4.126
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