Literature DB >> 22339074

Convection enhanced delivery of macromolecules for brain tumors.

Ankit I Mehta1, Bryan D Choi, Divya Ajay, Raghu Raghavan, Martin Brady, Allan H Friedman, Ira Pastan, Darell D Bigner, John H Sampson.   

Abstract

The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral infusion using a hydrostatic pressure gradient to transfer therapeutic compounds. The efficacy of CED is dependent on the distribution of the therapeutic agent to the targeted region. Here we present a review of convection enhanced delivery of macromolecules, emphasizing the role of tracers in enabling effective delivery anddiscuss current challenges in the field.

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Year:  2012        PMID： 22339074      PMCID： PMC7521418          DOI： 10.2174/157016312803305951

Source DB:  PubMed          Journal:  Curr Drug Discov Technol        ISSN： 1570-1638


  56 in total

Review 1.  Convection-enhanced delivery of therapeutics for brain disease, and its optimization.

Authors:  Raghu Raghavan; Martin L Brady; María Inmaculada Rodríguez-Ponce; Andreas Hartlep; Christoph Pedain; John H Sampson
Journal:  Neurosurg Focus       Date:  2006-04-15       Impact factor: 4.047

2.  Monitoring response to convection-enhanced taxol delivery in brain tumor patients using diffusion-weighted magnetic resonance imaging.

Authors:  Y Mardor; Y Roth; Z Lidar; T Jonas; R Pfeffer; S E Maier; M Faibel; D Nass; M Hadani; A Orenstein; J S Cohen; Z Ram
Journal:  Cancer Res       Date:  2001-07-01       Impact factor: 12.701

3.  Effects of drug efflux on convection-enhanced paclitaxel delivery to malignant gliomas: technical note.

Authors:  Philipp G Tanner; Markus Holtmannspötter; Jörg-Christian Tonn; Roland Goldbrunner
Journal:  Neurosurgery       Date:  2007-10       Impact factor: 4.654

4.  Real-time in vivo imaging of the convective distribution of a low-molecular-weight tracer.

Authors:  David Croteau; Stuart Walbridge; Paul F Morrison; John A Butman; Alexander O Vortmeyer; Dennis Johnson; Edward H Oldfield; Russell R Lonser
Journal:  J Neurosurg       Date:  2005-01       Impact factor: 5.115

5.  Tracking accuracy of T2- and diffusion-weighted magnetic resonance imaging for infusate distribution by convection-enhanced delivery.

Authors:  Rajiv R Iyer; John A Butman; Stuart Walbridge; Neville D Gai; John D Heiss; Russell R Lonser
Journal:  J Neurosurg       Date:  2011-06-10       Impact factor: 5.115

6.  Convection-enhanced delivery of macromolecules in the brain.

Authors:  R H Bobo; D W Laske; A Akbasak; P F Morrison; R L Dedrick; E H Oldfield
Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-15       Impact factor: 11.205

7.  Convection-enhanced delivery of free gadolinium with the recombinant immunotoxin MR1-1.

Authors:  Dale Ding; Charles W Kanaly; Darrell D Bigner; Thomas J Cummings; James E Herndon; Ira Pastan; Raghu Raghavan; John H Sampson
Journal:  J Neurooncol       Date:  2009-11-07       Impact factor: 4.130

8.  Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: from preclinical to phase I/II studies.

Authors:  Peter Hau; Piotr Jachimczak; Reimar Schlingensiepen; Frank Schulmeyer; Tanya Jauch; Andreas Steinbrecher; Alexander Brawanski; Martin Proescholdt; Jürgen Schlaier; Johanna Buchroithner; Josef Pichler; Gabriele Wurm; Maximilian Mehdorn; Rainer Strege; Gerhard Schuierer; Victoria Villarrubia; Franz Fellner; Olav Jansen; Thorsten Straube; Virinder Nohria; Michael Goldbrunner; Mechthild Kunst; Susanne Schmaus; Gerhard Stauder; Ulrich Bogdahn; Karl-Hermann Schlingensiepen
Journal:  Oligonucleotides       Date:  2007

9.  Effect of ependymal and pial surfaces on convection-enhanced delivery.

Authors:  Jay Jagannathan; Stuart Walbridge; John A Butman; Edward H Oldfield; Russell R Lonser
Journal:  J Neurosurg       Date:  2008-09       Impact factor: 5.115

10.  Safety, tolerability, and tumor response of IL4-Pseudomonas exotoxin (NBI-3001) in patients with recurrent malignant glioma.

Authors:  Friedrich Weber; Anthony Asher; Richard Bucholz; Mitchel Berger; Michael Prados; Susan Chang; Jeffrey Bruce; Walter Hall; Nikolai G Rainov; Manfred Westphal; Ronald E Warnick; Robert W Rand; Frank Floeth; Frank Rommel; Henry Pan; Vijay N Hingorani; Raj K Puri
Journal:  J Neurooncol       Date:  2003 Aug-Sep       Impact factor: 4.130
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  13 in total

1.  A model for optimizing delivery of targeted radionuclide therapies into resection cavity margins for the treatment of primary brain cancers.

Authors:  Raghu Raghavan; Roger W Howell; Michael R Zalutsky
Journal:  Biomed Phys Eng Express       Date:  2017-05-05

Review 2.  Convection-Enhanced Delivery.

Authors:  A M Mehta; A M Sonabend; J N Bruce
Journal:  Neurotherapeutics       Date:  2017-04       Impact factor: 7.620

3.  Preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats.

Authors:  Xuhui Bao; Vidyalakshmi Chandramohan; Randall P Reynolds; John N Norton; William C Wetsel; Ramona M Rodriguiz; Dipendra K Aryal; Roger E McLendon; Edward D Levin; Neil A Petry; Michael R Zalutsky; Bruce K Burnett; Chien-Tsun Kuan; Ira H Pastan; Darell D Bigner
Journal:  Invest New Drugs       Date:  2016-01-04       Impact factor: 3.850

Review 4.  Strategies for improving the intratumoral distribution of liposomal drugs in cancer therapy.

Authors:  Beth Goins; William T Phillips; Ande Bao
Journal:  Expert Opin Drug Deliv       Date:  2016-04-04       Impact factor: 6.648

Review 5.  Dendritic cell immunotherapy for solid tumors: evaluation of the DCVax® platform in the treatment of glioblastoma multiforme.

Authors:  Alia Hdeib; Andrew Edward Sloan
Journal:  CNS Oncol       Date:  2015

Review 6.  Image-guided interventional therapy for cancer with radiotherapeutic nanoparticles.

Authors:  William T Phillips; Ande Bao; Andrew J Brenner; Beth A Goins
Journal:  Adv Drug Deliv Rev       Date:  2014-07-09       Impact factor: 15.470

7.  Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma.

Authors:  Frederick F Lang; Charles Conrad; Candelaria Gomez-Manzano; W K Alfred Yung; Raymond Sawaya; Jeffrey S Weinberg; Sujit S Prabhu; Ganesh Rao; Gregory N Fuller; Kenneth D Aldape; Joy Gumin; Luis M Vence; Ignacio Wistuba; Jaime Rodriguez-Canales; Pamela A Villalobos; Clemens M F Dirven; Sonia Tejada; Ricardo D Valle; Marta M Alonso; Brett Ewald; Joanna J Peterkin; Frank Tufaro; Juan Fueyo
Journal:  J Clin Oncol       Date:  2018-02-12       Impact factor: 50.717

8.  Tumoricidal activity of low-energy 160-KV versus 6-MV X-rays against platinum-sensitized F98 glioma cells.

Authors:  Sara N Lim; Anil K Pradhan; Rolf F Barth; Sultana N Nahar; Robin J Nakkula; Weilian Yang; Alycia M Palmer; Claudia Turro; Michael Weldon; Erica Hlavin Bell; Xiaokui Mo
Journal:  J Radiat Res       Date:  2014-09-28       Impact factor: 2.724

9.  Convection-Enhanced Delivery of Carboplatin PLGA Nanoparticles for the Treatment of Glioblastoma.

Authors:  Azeem Arshad; Bin Yang; Alison S Bienemann; Neil U Barua; Marcella J Wyatt; Max Woolley; Dave E Johnson; Karen J Edler; Steven S Gill
Journal:  PLoS One       Date:  2015-07-17       Impact factor: 3.240

Review 10.  Overview of Methods for Overcoming Hindrance to Drug Delivery to Tumors, with Special Attention to Tumor Interstitial Fluid.

Authors:  Gianfranco Baronzio; Gurdev Parmar; Miriam Baronzio
Journal:  Front Oncol       Date:  2015-07-23       Impact factor: 6.244
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