BACKGROUND: The high variation in responses to bariatric surgery might be partially explained by genetic effects. Recently, common polymorphisms of the fat mass and obesity-associated gene (FTO) have been linked to obesity in some populations. Only two studies have investigated the effect of FTO variants on weight loss of morbid obese patients undergoing bariatric surgery with contradictory results. OBJECTIVE: We decided to investigate the role of the rs9939609 FTO gene polymorphism on outcomes after a biliopancreatic diversion surgery (BPD) in morbidly obese patients. DESIGN: A sample of 119 morbidly obese patients' body mass index (BMI) > 40 kg/m(2) were operated. Weight, fat mass, blood pressure, basal glucose, triacylglycerols, total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol were measured at basal visit and at each visit (basal, 3, 9 and 12 months). The frequency of metabolic comorbidities was recorded at each visit. RESULTS: Thirty-seven patients (31.1%) had genotype TT (wild type group), 58 (48.7%) patients had genotype TA and 24 patients (20.2%) had genotype AA. In the wild and mutant type groups, BMI, weight, waist circumference, systolic blood pressure and diastolic blood pressure decreased in a significant way. In the wild type groups, glucose, total cholesterol, low density lipoprotein (LDL) cholesterol and triacylglycerol concentrations decreased at 3, 9 and 12 months after surgery. In the mutant type groups, glucose, total cholesterol and triacylglycerol concentrations decreased at 3, 9 and 12 months after surgery. LDL cholesterol decreased at 9 and 12 months after surgery. Initial weight percent loss at 3 months of follow-up was higher in the wild type group (26.1% vs. 18.6%: p < 0.05). The initial weight percent loss at 9 or 12 months was similar in both genotypes. CONCLUSION: Our study showed a higher initial weight loss at 3 months after the TT variant of FTO gene (rs9939609). However, the weight loss at 9 and 12 months of BPD was similar in both genotypes with a significant improvement in biochemical parameters and cardiovascular comorbidities.
BACKGROUND: The high variation in responses to bariatric surgery might be partially explained by genetic effects. Recently, common polymorphisms of the fat mass and obesity-associated gene (FTO) have been linked to obesity in some populations. Only two studies have investigated the effect of FTO variants on weight loss of morbid obesepatients undergoing bariatric surgery with contradictory results. OBJECTIVE: We decided to investigate the role of the rs9939609FTO gene polymorphism on outcomes after a biliopancreatic diversion surgery (BPD) in morbidly obesepatients. DESIGN: A sample of 119 morbidly obesepatients' body mass index (BMI) > 40 kg/m(2) were operated. Weight, fat mass, blood pressure, basal glucose, triacylglycerols, total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol were measured at basal visit and at each visit (basal, 3, 9 and 12 months). The frequency of metabolic comorbidities was recorded at each visit. RESULTS: Thirty-seven patients (31.1%) had genotype TT (wild type group), 58 (48.7%) patients had genotype TA and 24 patients (20.2%) had genotype AA. In the wild and mutant type groups, BMI, weight, waist circumference, systolic blood pressure and diastolic blood pressure decreased in a significant way. In the wild type groups, glucose, total cholesterol, low density lipoprotein (LDL) cholesterol and triacylglycerol concentrations decreased at 3, 9 and 12 months after surgery. In the mutant type groups, glucose, total cholesterol and triacylglycerol concentrations decreased at 3, 9 and 12 months after surgery. LDL cholesterol decreased at 9 and 12 months after surgery. Initial weight percent loss at 3 months of follow-up was higher in the wild type group (26.1% vs. 18.6%: p < 0.05). The initial weight percent loss at 9 or 12 months was similar in both genotypes. CONCLUSION: Our study showed a higher initial weight loss at 3 months after the TT variant of FTO gene (rs9939609). However, the weight loss at 9 and 12 months of BPD was similar in both genotypes with a significant improvement in biochemical parameters and cardiovascular comorbidities.
Authors: C Razquin; J A Martinez; M A Martinez-Gonzalez; M Bes-Rastrollo; J Fernández-Crehuet; A Marti Journal: Int J Obes (Lond) Date: 2009-11-17 Impact factor: 5.095
Authors: M A Sarzynski; P Jacobson; T Rankinen; B Carlsson; L Sjöström; C Bouchard; L M S Carlsson Journal: Int J Obes (Lond) Date: 2010-08-24 Impact factor: 5.095
Authors: Tiina J Lappalainen; Anna-Maija Tolppanen; Marjukka Kolehmainen; Ursula Schwab; Jaana Lindström; Jaakko Tuomilehto; Leena Pulkkinen; Johan G Eriksson; Markku Laakso; Helena Gylling; Matti Uusitupa Journal: Obesity (Silver Spring) Date: 2009-01-29 Impact factor: 5.002
Authors: Marisela Villalobos-Comparán; M Teresa Flores-Dorantes; M Teresa Villarreal-Molina; Maricela Rodríguez-Cruz; Ana C García-Ulloa; Lorena Robles; Adriana Huertas-Vázquez; Nubia Saucedo-Villarreal; Mardia López-Alarcón; Fausto Sánchez-Muñoz; Aarón Domínguez-López; Ruth Gutiérrez-Aguilar; Marta Menjivar; Ramón Coral-Vázquez; Gabriel Hernández-Stengele; Victor S Vital-Reyes; Victor Acuña-Alonzo; Sandra Romero-Hidalgo; Doris G Ruiz-Gómez; Daniela Riaño-Barros; Miguel F Herrera; Francisco J Gómez-Pérez; Philippe Froguel; Eduardo García-García; M Teresa Tusié-Luna; Carlos A Aguilar-Salinas; Samuel Canizales-Quinteros Journal: Obesity (Silver Spring) Date: 2008-07-31 Impact factor: 5.002
Authors: Timothy M Frayling; Nicholas J Timpson; Michael N Weedon; Eleftheria Zeggini; Rachel M Freathy; Cecilia M Lindgren; John R B Perry; Katherine S Elliott; Hana Lango; Nigel W Rayner; Beverley Shields; Lorna W Harries; Jeffrey C Barrett; Sian Ellard; Christopher J Groves; Bridget Knight; Ann-Marie Patch; Andrew R Ness; Shah Ebrahim; Debbie A Lawlor; Susan M Ring; Yoav Ben-Shlomo; Marjo-Riitta Jarvelin; Ulla Sovio; Amanda J Bennett; David Melzer; Luigi Ferrucci; Ruth J F Loos; Inês Barroso; Nicholas J Wareham; Fredrik Karpe; Katharine R Owen; Lon R Cardon; Mark Walker; Graham A Hitman; Colin N A Palmer; Alex S F Doney; Andrew D Morris; George Davey Smith; Andrew T Hattersley; Mark I McCarthy Journal: Science Date: 2007-04-12 Impact factor: 47.728
Authors: Timo D Müller; Anke Hinney; André Scherag; Thuy T Nguyen; Felix Schreiner; Helmut Schäfer; Johannes Hebebrand; Christian L Roth; Thomas Reinehr Journal: BMC Med Genet Date: 2008-09-17 Impact factor: 2.103
Authors: Lu Qi; Kihwa Kang; Cuilin Zhang; Rob M van Dam; Peter Kraft; David Hunter; Chih-Hao Lee; Frank B Hu Journal: Diabetes Date: 2008-07-22 Impact factor: 9.461
Authors: Angelo Scuteri; Serena Sanna; Wei-Min Chen; Manuela Uda; Giuseppe Albai; James Strait; Samer Najjar; Ramaiah Nagaraja; Marco Orrú; Gianluca Usala; Mariano Dei; Sandra Lai; Andrea Maschio; Fabio Busonero; Antonella Mulas; Georg B Ehret; Ashley A Fink; Alan B Weder; Richard S Cooper; Pilar Galan; Aravinda Chakravarti; David Schlessinger; Antonio Cao; Edward Lakatta; Gonçalo R Abecasis Journal: PLoS Genet Date: 2007-07 Impact factor: 5.917
Authors: Natália Luiza Kops; Manoela A Vivan; Jaqueline D C Horvath; Mariana L D de Castro; Rogério Friedman Journal: Obes Surg Date: 2018-09 Impact factor: 4.129